Clinical Research On Therapy Of Renal-Vi Tal-Reinforce And Bone-Vital-Strong Prescription In Treating T2DM Osteoporosis

Purpose:To discuss the understanding of Traditional Chinese Medicine about type-2diabetes with osteoporosis, using the therapy of renal-vital-reinforce and bone-vital-strong prescription to treat type-2diabetes with osteoporosis.To observe the therapeutic efficacy of this prescription in treating type-2diabetes with osteoporosis liver-kidney deficiency symptoms by the indexes such as clinical symptoms,hormones,cytokines,bone mineral density.Then evaluate its curative effect and safety, so as to guide its clinical applicationMethods:A randomized,controlled trial was conducted.The patients of type-2diabetes with osteoporosis were randomly classified into two groups according to1:1paired matched.On the basic of normal treatment and western medicine, the patients of treated group were treated by Chinese medicine while the patients of controlled group were treated by Calcium Carbonate and Vitamin D3chewable tablets, observing for3month and four weeks made up of a course of treatment.The observed indexes included curative effect indexes,such as clinical symptoms, blood glucose,HbAlc,serum Calcium and Phosphate, Estradiol, Testosterone, IL-6, urinary calcium, BMD and so on.The complete data carries on statistics analysis by the SPSS16.0statistics software.Results:The study included type-2diabetic patients with50cases.25cases of treated group, while25cases of controlled group. Prior treatment,the gender, age, course of disease of the two groups patients had no differeces.1. Symptoms and signs improvement:the treated group after treatment had a significant improvement. The symptoms improvement of the treated group was better than the controlled group (P<0.01).2.Blood glucose:The FBG, PBG of treated group and controlled group were significantly lower(P<0.01); After treatment, the FBG of the treated group had a significant difference than controlled group(P<0.01).The PBG of treated group also had a significant difference than controlled group (P<0.05), The HbAlc of treated group also had a significant difference than controlled group (P<0.05).3. Bone mineral density:After treatment,the BMD of the treated group were significantly higher than controlled group(P <0.01).while the controlled group had no statistically significance(P>0.05).The BMD of the treated group had a significant difference than controlled group(P<0.05).4.Calcium and Phosphate:Serum calcium of the two groups were higher, but had no statistically significance(P>0.05).Serum phosphate of the two groups were lower, but had no statistically significance difference.Serum calcium and phosphate of the controlled group had no statistically significance difference(P>0.05).5.Hormone:In the male sufferer,after treatment,the E2of the treated group was visibly lower, had a significantly difference than controlled group(P<0.05), the T of the treated group was visibly higher, had a significantly difference than controlled group(P<0.01).The improvement of E2of the treated group had a significant difference than controlled group(P<0.05).the improvement of T of the treated group was better than the controlled group, but had no statistically significance difference(P>0.05).In the female sufferer, the E2of the treated group was visibly higher(P＜0.01), the T was visibly lower(P<0.01).The improvement of E2of the treated group was better than the controlled group(P<0.05), the improvement of T of the treated group was better than the controlled group, but had no statistically significance difference(P>0.05).6.IL-6:The IL-6of the treated group were also significantly improved(P<0.01), and had a significant difference than controlled group(P <0.05).7.Safety index:The routine blood/urine/feces test, and the liver and kidney function tests of treated group were within the normal range. Both groups had no unhealthy response.Conclusion:Through the preliminary clinical study, Bone-vital-strong prescription has obvious curative effected in treating type-2diabetes with osteoporosis liver-kidney deficiency symptoms. From the angle of western medicine, it can reduced blood sugar and HbAlc, improve BMD, decrease the excretion of urinary calcium, and adjust hormone.And, most importantly,be safe and effective.lt is worth studying deeply and developing further.Remarkable results have been achieved by bone-vital-strong prescription that reducing blood and improved BMD.But because of my ability and conditions limited as an overseas student, there were small number of cases and simple observational items in this study. And further investigations is required.