Study On Diagnosis And Treatment Rules Of Consumptive-thirst Disease Based On Data Analysis Of Ancient And Modern Medical Records

Objective:The dissertation aims to approach the historical origin and development of consumptive-thrist disease by collecting and unscrambling the information in ancient and modern medical records, to obtain the diagnosis and treatment rules implicit in the records using statistical method and data mining technique, and to analyze the evolution of the rules, thereby providing methodological reference for researches on traditional Chinese medical records, new thoughts for clinical diagnosis and treatment of consumptive-thrist disease, and clues for experimental research.Method:1. Ancient and modern medical records about consumptive-thrist disease are collected and sorted through to grasp their distribution in different period of history, to analyze and unscramble names, causes, pathogenesis and therapeutic methods of consumptive-thrist disease, which helps to get a thorough and systematic understanding about the historical development of consumptive-thrist disease.2. Using SAS9.1, frequency, factor, cluster, canonical correlation analysis and association rules are applied to explore connotative association of3aspects, including association among symptoms, association among drugs and association between symptoms and drugs, which helps to summize the evolution of diagnosis and treatment rules during3periods of history (Jin and Yuan Dynasty, Ming and Qing Dynasty and modern times) as well as location, pathogenesis, pathologic patterns and therapeutic rules of consumptive-thrist disease.Result:1. As a result of applying association rules to ananlyze the association among high-frequency drugs selected from all the medical records,42pairs of drugs are obtained and further divided into8groups according to their effect, namely nourishing yin and body fluid, tonifying cooperated with hydragogue and fire-lowering, tonifying kidney and spleen, tonifying qi and body fluid, heat-clearing and body fluid nourishing, yin nourishing, heat clearing and hydragogue and fire-lowering.2. Applying canonical correlation analysis to study the relation between high-frequency symptoms and drugs selected from all the medical records,17canonical correlation variables are obtained, and10combinations of syndrome and treatment can be extracted according to Traditional Chinese Medicine theory. The pathogenesis reflected by the10groups are liver-yang flaming, blood stasis, spleen deficiency accompanied with pathogenic dampness, qi deficiency and stagnation, heart and liver fire hyperactivity, lung and stomach dryness-heat, kidney yin deficiency, essence and blood deficiency, kidney yang deficiency and intestinal dryness caused by body fluid deficiency. Correspondingly,10therapeutic rules can be deduced:nourishing liver and tranquilizing yang, dissolving blood stasis and restoring function of blood, removing dampness to regulate stomach, tonifying qi and promoting flow of qi, clearing heart-fire and nourishing liver, clearing heat and nourishing body fluid, tonigying yin and astringing essence of kidney, nourishing essence and blood, warming yang to regain function of qi and moistening dryness and purging intestines.3. Analyzing the12selected high-frequency symptoms from medical records of Jin and Yuan Dynasty obtains3clusters which reflect the pathogenesis of yin deficiency and dryness-heat. Analyzing the46selected high-frequency drugs from medical records of the same period obtains6factors and7clusters which can be reduced to8therapeutic rules:clearing heat and fire, replenishing qi to invigorate the spleen, promoting flow of qi and dispelling dampness, nourishing yin for lowering fire, astringing essence, dissolving blood stasis and restoring function of blood, repressing liver yang and purging intestines.4. Analyzing the25selected high-frequency symptoms from medical records of Ming and Qing Dynasty obtains8factors and8clusters which can be reduced to6pathogenesis: spleen and kidney deficiency, dryness and heat caused by body fluid deficiency, internal heat flaming, lung and spleen deficiency, liver-yang flaming and phlegm stasis. Analyzing the60selected high-frequency drugs from medical records of the same period obtains10factors and10clusters which can be reduced to7therapeutic rules:nourishing yin and body fluid, replenishing qi to invigorate the spleen, dissolving blood stasis and restoring function of blood, warming kidney and regaining function of qi, clearing heat and fire, dispelling dampness and eliminating phlegm and reinforcing kidney to astringe essence.5. Analyzing the55selected high-frequency symptoms from medical records of modern times obtains10factors and11clusters which can be reduced to6pathogenesis:internal heat caused by yin deficiency, dryness and heat caused by body fluid deficiency, spleen dysfunction in transforming and transporting, qi stagnation and blood stasis, yang deficiency and water retention and pathogenic fire derived from liver depression. Analyzing the101selected high-frequency drugs from medical records of the same period obtains11factors and15clusters which can be reduced to10therapeutic rules:tonifying yin to clear heat, clearing heat and fire, tonifying spleen to regulate stomach, warming kidney and regaining function of qi, dispelling dampness to promote flow of qi, promoting circulation to dissolve blood stasis, nourishing liver and kidney, astringing essence, tranquilizing liver and smoothing liver-qi stagnation and tranquilizing mind and spirit.Conclusion:1. A thorough and systematic understanding about the historical development of consumptive-thrist disease and the evolution of diagnosis and treatment rules dealing with consumptive-thrist disease during3periods of history (Jin and Yuan Dynasty, Ming and Qing Dynasty and modern times) are obtained, which lay the basis for future research on literature.2. The pathogenesis of consumptive-thrist disease can be reduced to6aspects:yin, yang, qi, blood, dampness and blood stasis, according to which6pathologic types are established and the disease location is summrized, which provide reference for syndrome differentiation.3. Commom drugs treating consumptive-thrist disease and regularity in drug combinations are analyzed and concluded, which offer principles for forming prescription as well as clues for for experimental research.4.9therapeutic methods treating consumptive-thrist disease are conclued to conduct clinical treatment.5. New thoughts for clinical diagnosis and treatment of consumptive-thrist disease is concluded, which provides the basis for Traditional Chinese Medicine diagnosis and intervention of some modern disease:part of diabetes mellitus, diabetes insipidus, primary polydipsia and hyperthyroidism.