Clinical Research On Tangyou Jieyu Decoction In Treating Diabetes Mellitus Complicating Depression

Purpose-To investigate in medicine for type2diabetes mellitus complicating hypertension, through clinical studies, observation the mentor experience regimen Xiaotangjiangya decoction to improve type2diabetes mellitus complicating hypertension patients in symptoms, signs, blood sugar, blood pressure, glycosylated hemoglobinthe impact of blood lipids, blood rheology, insulin resistance index and pancreatic β-cell function index.To evaluate the clinical efficacy and safety, explore the mechanism of prevention and treatment of this disease,and to provide an objective basis for clinical application.Method:Randomized controlled study, would be consistent with type2diabetes mellitus complicating hypertension patients diagnostic criteria, were randomly divided into a treatment group and a control group. Decoct Chinese medicine Xiaotangjiangya decoction for treatment group of a daily regimen for three months on the basis of the basic treatment including hypoglycemic and antihypertensive medicine treatment. Before and after treatment were evaluated its symptoms, signs, blood sugar, blood pressure, glycosylated hemoglobin, lipids, insulin sensitivity index (IAI), hemorheological indicators, as well as in patients with adverse reactions, compliance. All data SPSS17.0statistical software for statistical analysis.Conclusion:Diagnosis and inclusion of type2diabetes mellitus complicating hypertension in patients of60cases (30cases of the treatment group and the control group of30patients), gender, age, duration before treatment, baseline data were statistically nosignificant differences comparable.①on the symptoms and signs of improvement:the treatment group patients symptoms markedly improved, the total effective rate was90.00%; control group, the total effective rate was73.33%. The TCM symptoms improve treatment group than the control group (P<0.01).②hypoglycemic antihypertensive effect:the treatment group and the control group of patients with blood glucose, blood pressure, glycated hemoglobin were significantly reduced compared with before treatment group showed a significant difference (P<0.01); fasting glucose improved in the treatment group compared with the control group significantly differences (P <0.01), treatment group, postprandial blood glucose, glycosylated hemoglobin, blood pressure improvement compared with the control group, differences (P<0.05).③lipid effect:patients treated with TC, TG, LDL-C treatment compared with the control group decreased (P<0.01), HDL-C increased (P<0.01) before treatment; patients in the control group TC levels decreased (P<0.01), HDL-C levels increased(P<0.01), but no significant difference in the TG, LDL-C before treatment. The comparison between groups TC, HDL-C, to improve the situation was no significant difference between the two groups.④the hemorheological:treatment group after treatment, whole blood viscosity (high cut, middle cut, low cut), plasma viscosity than before treatment decreased (P<0.05), whole blood viscosity control group (in middle cut) and plasma viscosity before treatment decreased (P<0.05), plasma viscosity (high cut, low cut) before and after treatment was no fifference. The decline of the treatment group, whole blood viscosity (excised) between the two groups compared with the control group had significant differences (P＜0.01), plasma viscosity decreased levels of the two groups was no significant difference (P>0.05). The two sets of hematocrit were no significant changes before and after treatment⑤FINS, HOMA2-IR, HOMA2-%B:After treatment, FINS and HOMA2-IR than treatment significantly lower (P<0.01), and HOMA2-%B than treatment also significantly higher (P<0.01).⑥security indicators:liver and kidney function tests were within the normal range. Both groups were no adverse reactions.Conclusion:View from preliminary clinical studies, treatment with Western medicine combination Xiaotangjiangya decoction effect better than the only western medicine, Chinese medicine treatment can improve the clinical symptoms of patients with hypertension and type2diabetes, lower blood sugar, blood pressure, regulate blood lipids,can improve blood rheology and safe, effective, and has a broad application prospects, and worthy of further study.