The Role Of P42.3 Gene In Human Colorectal Cancer

OBJECTIVE:This article aimed to investigate the expression of p42.3 gene in normal colorectal mucosa, those with precancerous lesions and cancer tissues. We especially focused on patients who had 2 or more colonoscope records, to evalute the potential role of p42.3 gene in predicting occurence of advanced adenomas and colorectal cancer(CRC).Method: Immunohistochemical staining was employed to detect the P42.3 protein’s expression in colorectal mucosas with different degree of dysplasia. In addition, 391 specimens collected during Jan 1,2008 and Dec 31,2012 in Gastroenterology Department of Renji Hospital, Shanghai, which were from patients who experienced more than 2 times colonoscope were utilized to evalute the relation between P42.3and prognosis of colorectal adenomas.Result: P42.3 protein was demonstrated to be over-expressed in colorectal mucosas with severe dysplasia and CRC tissues compared with in normal mucosas(sperately with a P value of 0.016 and 0.032). There were a positive rate of 32.23%, 47.94%,96.10% and 81.32% in group of normal tissues, slight-median dysplasia, severe dysplasia and CRC, which suggested a gradually increasing trend. P42.3 protein showed a higher level in patients with reoccurence of adenomas. It showed male patients, those who were older than 65 years old or had advanced adenomas in first colonoscope had higher rate of recurrence, both for nonadvanced and advanced adenomas. Patients with P42.3-positive mucosas had higher risk to suffer recurrence of adenomas. However, no significant difference between expression of p42.3 had been found in patients who suffered reoccurence of advanced adenomas.Cox regression showed no prognostic function of P42.3 in occurrence of AA and CRC.Conclusion: The results indicatd that p42.3 gene might play a role in the progression of colorectal mucosal hyperplasia and CRC. However, there was no proof to support its function in predicting occurence of advanved adenomas.