Study On The Health Of Diminished Ovarian Reserve Patients’ Offspring Conceived By Assisted-Reproductive Technologies

Ovarian reserve views reproductive potential as a function of the number and quality of remaining oocytes, which can reflect the function of ovary. DOR (diminished ovarian reserve) describes women of reproductive age having regular menses whose response to ovarian stimulation or fecundity is reduced compared with women of comparable age. DOR may result in the change of quantity and quality of remaining oocytes, as well as fecundity. DOR has been reported correlate with poor ovarian response, high cancellation rate and fail to conceive. For now, studies on the quality of oocyte of DOR patients are all about its fertility and the implantation capacity of blastocyst. Whether DOR may influence oocytes on the health of the offspring has not been reported. Thus, we employ this study to illuminate that. According to the basal FSH, we divided those patients who accordance with the inclusive criteria into two groups. Those basal FSH greater than10IU/L and less than40IU/L are divided into DOR group, and those basal FSH equal or less than10IU/L are divided into NOR(normal ovarian reserve) group. The oocytes obtained in ART are significantly decreased in DOR group compared with NOR group. The IQ and rate of neonatal jaundice/congenital anomalies/high blood pressure/hyperlipidemia/abnormal FBG/abnormal liver function/abnormal thyroid function show no significant difference between the offspring of the two groups. Conclusion:The quality of DOR patients’ oocytes does not change concerning the offsprings’ health.