| Objective:Hodgkin’s lymphoma (HL) are closely associated with Epstein-Barr virus (EBV) infection, and EBV infection rate is different between regions and races. The aim of our study is to evaluate the EBV status in the previously untreated Hodgkin’s lymphoma in our hospital and investigate the prognostic significance of EBV status in HL.Methods:According to the classification of WHO criteria of lymphoma, a total of 207 previously untreated patients with histologically confirmed Hodgkin’s lymphoma in our hospital were enrolled in the this study. The EBV infection status was confirmed through the in situ hybridization method by detecting Epstein-Barr Virus Encoded RNA (EBER) or immunohistochemical method by detecting the Latent membrane protein-1(LMP-1) expression in the tissue specimens. The clinical characters, treatment methods, treatment response rate and survival information were collected and analyzed. We also investigated the prognostic significance of EBV-association in HL, analyze the clinical features and EBV infection status in pediatric HL and the elderly HL.Results:From 329 patients with HL treated in our center since February 2008 to October 2014,207 patients were selected. As a result,66 cases were confirmed to be EBV positive Hodgkin’s lymphoma (EBV+HL) in all 207 cases, accounting for 31.9%. The most common histological type was mixed cellularity (52.9%) in EBV positive group (EBV+HL) and EBV+HL group had higher proportion of male patients than the EBV-HL group (69.7% vs 49.6%, P= 0.005), more common with higher Beta-2 microglobulin. In the age layer analysis, the EBV+HL group had more patients in childhood and the elderly than the EBV-HL group (13.6% vs 7.1%,15.2% vs 2.8%, P< 0.001). Compared between different regions, patients in the western region had higher EBV positive rate than patients in other than other regions. In prognostic analysis, OS was significantly better for EBV-HL group than EBV positive patients (P< 0.05), but there was no significant difference in PFS (P=0.761). Elderly patients had worse survival than others, and the OS was shorter in lower serum albumin group. EBV positive was the only independent poor prognostic factor for overall survival time, No radiation and elderly patients were associated with poor progression-free survival time.In pediatric HL group, there were 19 patients, the median age 12-ys old and the EBV-positive rate was 47.4%.The EBV-positive rate in 0-9 year-old group and 10-15 year-old were 66.7%,38.5%.All patients got CR and had long term survival. In the elderly HL group, there were 16 patients, the median age 65-ys old and the EBV-positive rate was 75.0%. The most common histological type was mixed cellularity (68.8%). The patients who had received radiotherapy had better survival than the patients who had not.Conclusion:EBV infection have a certain correlation with Hodgkin’s lymphoma. The EBV positive rate was 31.9% in our center, higher rate in children and elderly patients. The most common pathological type in EBV+HL was with mixed cellularity. EBV positive patients had short OS than EBV negative groups. |
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