| Background of researchChronic fatigue syndrome (CFS) is a set of unexplained persistent or recurrent chronic fatigue syndrome as the main feature. As the incidence of chronic fatigue syndrome showed an increasing trend, especially in developed countries, the incidence of up to14%-29%. This disease increasingly attach great importance to the medical profession. At present, research on chronic fatigue syndrome has become one of the hot topics in the field of medicine, psychology and sociology.Modern medicine, no special targeted therapies, symptomatic treatment, not a fundamental solution to the suffering of patients, while the Chinese medicine according to the various stages of the chronic fatigue syndrome clinical manifestations, from the overall concept syndrome typewith the disease and treatment, access to good effect. Acupuncture treatment of chronic fatigue syndrome with its safe, simple, inexpensive, and significant effect in clinical widely and quickly carried out, thus becoming an important method for the treatment of chronic fatigue syndrome. The subject on the basis of the summary of chronic fatigue syndrome in the Western literature, randomized controlled study, electro-acupuncture, Chinese medicine treatment as a control group, by observing the different treatments for heart and spleen chronic fatigue syndrome clinical efficacy explore the warm acupuncture, electro-acupuncture, Chinese medicine treatment of the clinical efficacy of three different therapies, cure feasibility and its problems, for the promotion of warm acupuncture treatment of chronic fatigue syndrome in future clinical significance. Object iveThe purpose of this study focuses on warm acupuncture in the treatment of heart and spleen of chronic fatigue syndrome clinical efficacy and immune mechanism. Temperature in this study acupuncture and electro-acupuncture, Chinese medicine treatment were compared to investigate the warm acupuncture, electro-acupuncture treatment, the difference of the clinical efficacy of traditional Chinese medicine treatment of heart and spleen of chronic fatigue syndrome, chronic fatigue syndrome patients immune function, such as the humoral immune level measured (serum IgG, IgA, IgM, C3and C4), cell immunity level of determination (CD3+, CD4+, CD8+content), in order to reveal its mechanism of action, while from chronic fatigue syndrome for the clinical treatment to provide a more effective therapy.MethodsThis clinical study cases from acupuncture clinics in Taiwan benevolence treatment of chronic fatigue syndrome patients, collection time from October2011to February2013, all cases are in line with the screening criteria, in line with the heart and spleen deficiency of both TCM syndromespatients signed an informed consent form agreeing to participate in this study. Collected a total of99cases, which warm acupuncture group of33cases, electro-acupuncture group of33cases, traditional Chinese medicine group of33cases. Western diagnostic criteria with reference to the November1994U. S. Centers for Disease Control (Centers for Diseases Control and Prevention, CDC) revised diagnostic criteria for CFS. The TCM syndromes reference Chinese medicine clinical research guidelines issued by the Ministry of Health to develop heart and spleen deficiency of both standards. The efficacy of specific projects include:the clinical efficacy of TCM syndromes score, fatigue scale (FS-14), self-rating anxiety scale (SAS), the Quality of Life Scale (WHOQOL-BREF), determination of the level of humoral immunity (serum IgG, IgA, IgM, C3, and C4), the determination of cellular immunity (peripheral blood CD3+, CD4+, CD8+). Overall efficacy criteria with reference to the "American Journal·Chinese medicine Volume Chinese medicine diagnosis and treatment of chronic fatigue syndrome Standard of" intended.ResultsPre-treatment the warm acupuncture group, the Chinese Medicines, the EA group sex, age, duration of disease, heart and spleen TCM clinical efficacy score, fatigue scale (FS-14), self-rating anxiety scale (SAS), survivalMeasurement Scale of Quality (WHOQOL-BREF), determination of the level of humoral immunity (serum IgG, IgA, IgM, C3and C4), determination of cellular immunity (peripheral blood CD3+, CD4+, CD8+) analysis were not statistically significant, IIIgroup general information and clinical baseline data were comparable.①he comparison of deficiency of heart and spleen syndromeAfter three courses:traditional Chinese medicine group, heart and spleen TCM clinical efficacy score and pre-treatment of the warm acupuncture group compared to the significantly reduced, the difference was statistically significant (P<0.01), EA group, the TCM clinical eff icacyscore lower than before treatment were significantly different (P<0.05). Between the two groups regard, the Chinese Medicines score than the EA group decreased (P <0.05). Tip:after a course of treatment, the the three therapy for the heart and spleen chronic fatigue syndrome clinical symptoms, such as body tired fatigue, Shenpi lazy words, palpitations, insomnia and more dreams, reduce appetite or poor appetite, there was no significant improvement in function; after three courses of treatment, warm acupuncture, electro-acupuncture group, Chinese group to alleviate the symptoms of heart and spleen of chronic fatigue syndrome have varying degrees of efficacy, to CMB most obvious, and EA group there are some differences in efficacy.②The comparison of fatigue scale (FS-14)Three groups after three courses fatigue scale (FS-14) score than before treatment, the difference was statistically significant (P<0.05), in order to warm acupuncture decreased significantly in group (P<0.05). Group comparisons, warm acupuncture group than the EA group score decreased (P<0.05). Tip:after a course of treatment, the temperature acupuncture treatment on the heart and spleen fatigue symptoms of chronic fatigue syndrome, which has a certain improvement, but the electro-acupuncture, Chinese medicine treatment was stopped short-term symptoms of fatigue; through three course of treatment, warm acupuncture, electro-acupuncture group, Chinese group to alleviate the heart and spleen chronic fatigue syndrome in patients with symptoms of fatigue different degrees of efficacy, the temperature the clinical efficacy of acupuncture is the most prominent.㏕he comparison of Self-Rating Anxiety Scale (SAS) Warm acupuncture group after three courses anxiety self-rating scale (SAS) score than the scores before treatment significantly reduced, the difference was statistically significant (P<0.01); EA group, the Chinese Medicines and pre-treatment difference was statistically significant (P<0.05); between the two groups, the three sets of pairwise comparisons, anxiety Rating Scale (SAS) score were not statistically different (P>0.05). Tip:After a course of treatment, there was no significant effect of three therapies for improving heart and spleen anxiety symptoms of chronic fatigue syndrome, after two courses, the EA group and warm acupuncture group can reduce the anxiety of chronic fatigue syndrome Rating; after three courses of treatment, warm acupuncture group, EA group, the Chinese Medicines for improving heart and spleen chronic fatigue syndrome in patients with symptoms of anxiety a certain role, but three kinds of therapy to reduce the role of anxiety symptoms similar.④The comparison of Quality of Life Scale (WHOQOL-BREF)Three treatment after warm acupuncture group, the Chinese Medicines Quality of Life Scale (WHOQOL-BREF) rating than the pre-treatment scores improved significantly, the difference was statistically significant (P <0.01); electro-acupuncture group compared with before treatment difference was statisticallysignificant (P<0.05); between the two groups, the to warm acupuncture group, Chinese medicine group and EA group compared to the quality of Life scale (WHOQOL-BREF) score improved statistically significant (P<0.05). Tip:Three therapies for improving the quality of life of the heart and spleen of chronic fatigue syndrome Determination Scale (WHOQOL-BREF) had no significant effect in the short-term efficacy of the rating; After three courses of treatment, warm acupuncture group, EA group, the Chinese Medicines for improving heart and spleen chronic fatigue syndrome patient quality of life have a certain role to warm acupuncture and traditional Chinese medicine treatment more significant.⑤omparison of Determination of the level of humoral immunityAfter three courses of treatment, warm acupuncture Serum C3, C4and traditional Chinese medicine group, EA group compared to the difference was statistically significant (P<0.05). Tip:After three courses of treatment, warm acupuncture group, Chinese medicine treatment lgG, IgM content have tended to increase, IgA content on a downward trend, but the difference was not statistically significant (P>0.05). Warm acupuncture treatment can significantly reduce heart and spleen chronic fatigue syndrome patients with serum C3, C4, more obvious than the electro-acupuncture, Chinese medicine treatment. Warm acupuncture abnormal state of fatigue in patients with chronic fatigue syndrome, heart and spleen complement levels corrective action, and significantly better than the EA and the Chinese Medicines. After three courses of treatment, warm acupuncture Serum C3, C4and traditional Chinese medicine group, EA group compared to the difference was statistically significant (P <0.05). Tip:After three courses of treatment, warm acupuncture group, Chinese medicine treatment lgG, IgM content have tended to increase, IgA content on a downward trend, but the difference was not statistically significant (P>0.05). Warm acupuncture treatment can significantly reduce heart and spleen chronic fatigue syndrome patients with serum C3, C4, more obvious than the electro-acupuncture, Chinese medicine treatment. Warm acupuncture abnormal state of fatigue in patients with chronic fatigue syndrome, heart and spleen complement levels corrective action, and significantly better than the EA and the Chinese Medicines.⑥Comparison of Determination of cellular immunityAfter three courses of treatment, the temperature in the acupuncture group peripheral blood CD3+, CD8+compared with the EA group, the difference was statistically significant (P<0.05); of warm acupuncture group compared with the traditional Chinese medicine group, peripheral blood CD8+increasedthere is a statistically significant difference (P<0.05). Tip:After three courses of treatment, warm acupuncture group CD3+, CD8+content than the EA group was significantly higher, between the two groups statistically significant difference (P<0.01), compared with the traditional Chinese medicine group, warm acupuncture group peripheral blood CD8+increased significant difference (P<0.05), indicating that warm acupuncture therapy for the improvement of the content of the cell-mediated immunity than the control group.⑦Comparison of the overall effect of the three groups after treatmentWarm acupuncture group, EA group, Chinese medicine treatment by Kruskal Wallis H rank test, H=3.28, P=0.046the three overall efficacy difference was statistically significant (P<0.05), in which warm acupuncture groupThe number of29people, the total effective rate was87.9%; the EA group total effective number of19, the total effective rate was57.6%; Chinese medicine group, the total effective number of21, the total effective rate was63.3%. Tip:warm acupuncture paste the treatment of heart and spleen chronic fatigue syndrome compared with electro-acupuncture, Chinese medicine treatment, significant clinical efficacy. Warm acupuncture group, EA group, Chinese medicine treatment by Kruskal Wallis H rank test, H=3.28, P=0.046the three overall efficacy difference was statistically significant (P<0.05), in which warm acupuncture groupThe number of29people, the total effective rate was87.9%; the EA group total effective number of19, the total effective rate was57.6%; Chinese medicine group, the total effective number of21, the total effective rate was63.3%. Tip:warm acupuncture paste the treatment of heart and spleen chronic fatigue syndrome compared with electro-acupuncture, Chinese medicine treatment, significant clinical efficacy.ConclusionThe research preliminary results suggest that the clinical efficacy of warm acupuncture, electro-acupuncture, herbal therapy for the treatment of heart and spleen chronic fatigue syndrome have achieved, but warm acupuncture back-shu points on the heart and spleen chronic fatigue syndromeimprovement of clinical symptoms significant effect, significantly better than the EA group and Chinese medicine group, fatigue scale-14points and anxiety Scale (SAS) scale score decreased significantly; patient’s individual symptoms have been significantly improved, especially in the bodytired fatigue, memory or decreased attention, tired after continuous discomfort, muscle pain improvement of the four individual symptoms are more prominent. And be able to correct abnormal heart and spleen in patients with chronic fatigue syndrome fatigue complement levels, to improve the content of cell-mediated immunity. Warm acupuncture treatment of heart and spleen chronic fatigue syndrome, reduce fatigue, reducing the patient’s family and social emotional burden and financial burden of great significance, the patient’s ability to work, social skills, daily life is restored, significantly improve the the patient’s quality of life. |
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