| Diabetic peripheral neuropathy (DPN) is the most common chronic diabetic complications, is one of diabetes (DM) disability or even death of the most common reasons. With modern society, people’s living standards improve, people changing lifestyles and an aging population trends, issues, trends are such that the incidence of diabetes is constantly rising, according to the World Health Organization (WHO) experts predict2025in patients with diabetes will reach300million people, now has been identified as cancer and cardiovascular disease following ranked third after the killer, and one of DPN patients accounted for approximately50%-80%, showing a high incidence of DPN. The clinical presentation is more complicated, mostly for the sensory and autonomic nerve involvement, often with relatively mild symptoms of motor neuron damage, especially in peripheral nerve damage. Generally prevalent mainly in the distal extremities, lower extremity limb is relatively heavy, early stage mainly sensory dysfunction, and can be presented separately distal symmetric bilateral limb numbness, sensory loss, cold, pain, shock sense, they are also some patients showed severe distal limb burning pain, unbearable at night cause insomnia and other symptoms caused by, sparking hypokinesia, muscle atrophy and even disability. Therefore, aggressive treatment of diabetic peripheral neuropathy in reducing diabetes morbidity and mortality, to further improve the quality of life of patients has important significance.1A theoretical part(1) DPN literature data compilationWestern medicine treatment of DPN by evidence-based medicine currently no effective drug treatment proven clinically effective medicine available research also rarely. This paper systematically analyzes and summarizes the ancient physicians and modern medical home awareness of diabetic peripheral neuropathy and diabetic peripheral neuropathy on Modern Research progress. Discussion on the Mechanism for DPN, Cho country medicine that symptoms of the disease in accordance with its attribution "Arthralgia","atrophy card" and other areas of medicine through its multi-target mechanism of action featured in the treatment of DPN highlight the advantages. Most modern scholars believe that the disease can be attributed to the merger Diabetes Arthralgia, Weizheng category. And its pathogenesis and treatment related to in-depth research carried out, although the physicians in its etiology, pathogenesis has transformed many different perspectives, but generally agree that the disease is due to the lack of righteousness, caused by blood loss of yin and yang, dysfunctional organs, leading to stagnation meridian evil, because blood does not moisten bones and disease. Mostly on the clinical treatment of blood circulation, nourishing, spleen and kidney, phlegm meridians other governing law(2) DPN six by the Diagnosis and Treatment LawTreatise on the Theory of diabetes pathogenesis, diagnosis and treatment of all aspects of detailed records, but for diabetic peripheral neuropathy (DPN) but no mention about the exact name of disease, relevant literature is extremely limited, and from clinical point of view, DPN mostly Chinese medicine,"Arthralgia","blood paralysis","syncope","insensitive","pulse Bi","atrophy card" and other areas. The main clinical symptoms seen:apathetic, hands and feet against the cold, body weight (muscle weakness, muscle atrophy, or paralysis), pain, itching, etc.,"Febrile Diseases," there are a lot of exposition. These were associated with diabetic peripheral neuropathy modern description of symptoms consistent with a great place.Finishing mentor Professor Professor Zhu Zhangzhi Treatment of DPN years of clinical experience, to provide and enhance the diagnosis and treatment of DPN Six TCM drugs on the basis of clinical and ideas.(3) The literature data compilation of Acupoint applicationPatching therapy has a long history, according to this clinical study, the spleen dampness proof stickers for dressing selection to "Treatise on" The Dangguisini soup as the main square, meaning that whichever function with the temperature by scattered cold, nourishing tongmai of power, deficient cold medicine that does not reach the distal extremities stagnate due to the cold nourishing treatment. This party is "TCM diagnosis of diabetic peripheral neuropathy draft norms" included, as a treatment for DPN Yang Hanning permit the main square, so in this study the main square Dangguisini soup to treat spleen alpine type DPN.2clinical part(1) Background:Diabetic peripheral neuropathy is currently lacking a unified view Pathogenesis understanding and treatment system standardization and standardization of Chinese medicine is still required for this disease have a more systematic study,"Treatise on" with "yin and yang business health, organs and meridians, blood and body fluids, phlegm and blood "of the theory, recognize six is run by the camp David on the road, through the Six Evils from male to female, from the real to the imaginary, from transit organs, dirty mass change the law, and thus reflects the Six physiological state and pathological outcomes.(2) Objective:①From the current research point of view, diabetic peripheral neuropathy Western pathogenesis is not completely understood, there is a variety of theories, such as the structure and function of microvascular abnormalities, polyol pathway activation, inositol metabolism, non-enzymatic tissue protein glycosylation, lipid metabolism abnormality, genetic factors, clinical pathogenesis given for the control of high blood sugar, vitamins, inositol, application aldose reducing agents, vasodilators, anti-oxidants, neurotrophic factors, and for the treatment of treatment of symptoms, but the overall effect is not ideal, in improving limb numbness and pain symptoms limited efficacy. Within this study, clothing and topical use of Chinese medicine to intervene in ways diabetic peripheral neuropathy treatment to increase its efficacy to improve symptoms.②In this study,"Treatise on" the six meridians system with TCM diagnostics, to explore the diagnosis and treatment of DPN basis and by the side of sticking (Angelica SND) the use of the ideas, and to further explore the use of cold by the side sticking therapy wet muscle paralysis Diabetes type spleen secondary advantage.(3) Methods:In this study, bibliographic references to understand the etiology and pathogenesis of DPN and the syndrome and law to medicine diagnosis thinking and "Treatise on" the six meridians system analysis of the pathological changes of diabetic peripheral neuropathic pain mechanisms within the service and topical way to treat and increase improve the symptoms of its efficacy. And to study the use of modern medicine "Toronto (Toronto) Clinical Neuropathy Scoring System (TCSS) survey","alpine storm Spleen symptoms graded quantization table" as numbness measure to improve the situation. Meets the standard90patients with type2diabetes patients with peripheral neuropathy, according to the control group, the treatment group and the placebo group=1:1:1ratio of randomized assignment, in which30patients (conventional treatment), the treatment group,30cases (conventional treatment+paste dressing), the placebo group30cases (conventional treatment+sticking flour).(4) Results:90patients admitted to hospital a month after the clinical observation, sticking therapy for peripheral neuropathy results show Question:the statistical analysis results suggest that the treatment group had better effects in neurological symptoms, neural reflex and sensory experiments than the comfort group and control group (P<0.05); The comfort group score had a better result than control group in neurological symptoms, neural reflex (P<0.05), while being the same as control group in sensory experiments (P>0.05). Prompt indicates that the treatment group has a significant effect, further explained in the treatment of spleen alpine type diabetic peripheral neuropathy patients, based on the square sticking (Angelica SND) to improve limb numbness and pain symptoms, with a significant superiority effect.In Chinese medicine treatment of spleen-type muscle paralysis alpine symptoms of study, results showed that:After one month of treatment, all kinds of clinical symptoms integral are improved in three groups; five symptoms The treatment group had better effecst in the treatment in stay eating less sodium, greasy mouth, head body is trapped, aromatic, belly full than other two groups (P<0.05), and comforted group were slightly better than the control group (P<0.05). Prompt Description medicine sticking treatment groups in improving clinical symptoms and overall superior to placebo control group, while the flour sticking to the placebo in improving clinical symptoms slightly better than the control group; efficacy assessment in the calculation, the treatment group TCM symptomatic treatment, the effective rate was80%,20%invalid; TCM symptoms placebo effect, the effective rate was60%,40%invalid; efficacy of Chinese medicine symptom control group, the effective rate was40%,60%invalid. Tip medicine treatment groups sticking spleen dampness in improving the clinical symptoms, the overall significantly better than the placebo group and the control group. From this study, in order to ask for the treatment of patching way to do help, it can be clearly seen that Chinese medicine in the treatment of this disease and the effectiveness of various aspects.(5) Conclusion:Diabetic peripheral neuropathy is the most common chronic complications of diabetes, one can involve sensory, motor and autonomic nerves. The most common type is the clinical distal symmetric sensory peripheral neuropathy. The clinical features manifested as cold, numbness, burning sensation, can not even tolerate clothing friction.Professor Zhu Zhangzhi career in medicine for many years, lapping "Treatise on" sympathetically, from "six meridians" Treating diabetes and its complications,"the first resolution of yin and yang," as the basis for the six meridians Dafa, promoting Heaven one, five and Six principles for the treatment. That:Nowadays people’s living standards improve, people in the diet and habits are changing, many prefer eating Feiganhouwei further and damage the stomach, affect the operation of the spleen and stomach function, leading to phlegm stop together. Guangdong Lingnan region plus summer long and hot weather, sweat pores open, muscle Teng not dense, very cold in the invasion, then sweat more easily hurt yang; Secondly, the modern air-conditioned environment people are often in the summer, but this cold the cool air of the gas, can be regarded as a kind of non-time atmosphere, and easily hurt yang; Furthermore, summer, hot weather, most people love eclipse cold food, frozen drinks, easily lead to cold evil straight in the coke, injury spleen yang; Finally, today’s society, people lead busy lives, nightlife, most people compared with the period of the agricultural society are more inclined to stay up late, does not enter the yin yang yang depletion of easily understood. Therefore, patients with DPN common clinical manifestations of obesity, more than enough cold sweat, bloating, poor appetite, moving the shortness of breath, thick white fur or tired, pale tongue, side teeth marks, weak pulse, etc., are yang dampness of the pulse card, summed up the "yang wet stasis stasis" is the key pathogenesis of DPN and common syndromes. |
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