Clinical Observation Of Treating Glomerular Proteinuria Individualized According To Age

Proteinuria is a main clinical manifestation in chronic renal disease.It has vital clinical significance, and has important effect on the length of time which patients with kidney disease enter the end stage renal failure. Science researchers and clinicians are actively seeking the effective ways of reducing protein in the urine. Chinese medicine treatment can reduce proteinuria, inhibit recurrence, stabilise symptoms and reduce the side effects of other drugsObjective:To observe the patients with primary chronic glomerular disease and to find the symptoms characteristics in each age groups. We established diffident therapeutic methods in TCM according to the different age groups, treated patients with traditional Chinese medicine for3months in order to observe the curative effect difference with the control groups.Methods:Test1included552patients with primary chronic glomerular disease. Clinical data was collected to explore the relationship between age and syndrome type. Test2included120patients with primary chronic glomerular disease, divided into three groups. A group includes patients from0to20years of age, B group includes patients from21to60years, C group includes patients over61years old. Each group includes40patients. These patients were randomly divideded into treating group and control group. Both groups were given basic treatment and the treatment group was given Chinese herbs at the same time. A treatment group was given the decoction of invigorating spleen and kidney. B treatment group was given the decoction of regulating Qi and invigorating kidney. C treatment group was given the decoction of activating blood and invigorating kidney. Therapeutic effect was observed at3months.Results:1The syndrome of asthenia in origin and asthenia in superficiality is more obvious ly in cl inic syndrome di f ferent iat ion among the pat ients with proteinuria as the main clinical manifestation of chronic glomerular disease.2Among the patients with proteinuria as the main clinical manifestation of chronic glomerular disease, weak spleen and kidney syndrome is the main cl inical type in the pat ients under the age of20. Weak spleen and kidney syndrome is the main clinical type in the patients under the age of20. Syndrome of qi stagnation is the main clinical type in the patients between the age from21to60. Syndrome of blood stasis is the main clinical type in the patients over the age of61.3Compaired with treating group and control group, integral of syndrome of Traditional Chinese Medicine descented obviously in three groups(P<0.05).4Compaired wi th treat ing group and control group,24h urine protein quant i ty is not statistically significant before receiving the treatment.24h urine protein quantitative decrease after treatment in each group, the result is statistically significant (P<0.05)Conclusion:1. There are different syndrome characteristics in different age patients with primary chronic glomerular disease. Weak spleen and kidney syndrome is the main cl inical type in the pat ients under theage of20. Syndrome of qi stagnation is the main clinical type in the patients between the age from21to60. Syndrome of blood stasis is the main clinical type in the patients over the age of61.2. Patients were divided into three groups according to ages. Three groups were treated the decoction of invigorating spleen and kidney, the decoction of regulating Qi and invigorating kidney, and the decoction of activating blood and invigorating kidney Compaired with treating group and control group, integral of syndrome of Traditional Chinese Medicine descented obviously in three groups(P<0.05),24h urine protein quantitative decrease after treatment in each group (P<0.05). It suggests that treatment individualized according to age have clinical significance in the treatment of proteinuria.