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Studies On The Coumarin Based Fluorescent Chemosensors For Heavy Metal Ions

Posted on:2009-11-23Degree:DoctorType:Dissertation
Country:ChinaCandidate:M X WangFull Text:PDF
GTID:1118360242495840Subject:Organic Chemistry
Abstract/Summary:PDF Full Text Request
This paper outlines the theory of electron transfer and ion chemosensors of the latest research progress, Comprehensive studies of optical properties of the fluorescent Coumarins and develops fluorescent chemosensors of copper and silver ions, and uses Ion fluorescent chemosensors for live liver tumor cells, to good effect, for further studies of the trace element metabolism to provide an effective means.First, design and synthesize two copper fluorescent chemosensors. Coumarins have good cell compatibility, better anti-tumor effect, and this compounds have strong fluorescence quantum number, N, N-dicarboxyl, and dipyridyl molecular derivatives were coupled at the 4-position with diazotized 7-amido-4-methyl-coumarin, we have two types of new fluorescent molecules. They have respective optical properties and the selectivity and sensitivity of copper ions. Therefore, by advanced confocal laser scanning microscope (LSM), we further study the copper chemosensors response to the copper ions in liver cancer cells. Experiments show that the Cu2+ do exist in the liver tumor cell, prove the forecast of thermodynamics: copper ions present in cells.Then, design and synthesize a silver metal ions fluorescent chemical sensor. We have overcome selectivity of silver ions fluorescent chemosensor is not high reported in the literature, and use toxic intermediates. To develop better selectivity Ag+ ion chemosensor, we use thiosulfate carbonate group as the recognition of ion group that have rarely be used for other chemosensor Ag+, in order to enhance identification group on the Ag+ selectivity, we have chosen the Hexahydropyridine without N, N-dimethylformamide, to increase recognition of the group steric hindrance. Subsequent research showed that the new test compounds for Ag+ has good selectivity.
Keywords/Search Tags:Chemosensors
PDF Full Text Request
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