H. Pylori Infection In Patients With Ear Aided Diagnosis

Helicobactor (Helicobacter pylori, Hp) is currently classified as class I of biological carcinogenic factor by the International Agency for Research into Cancer (IARC), a subsidiary unit in the World Health Organization (WHO). Helicobactor infection rates have reached more than 50% in the current global population and in many developing countries, becoming a potential risk factor which seriously endangers the health. HP infection has grown into a worldwide problem. A number of studies have confirmed that HP is an important risk factor of upper gastrointestinal diseases and serious complications of disorders other than gastrointestinal track.China is a developing country, Hp infection rates are relatively high. National epidemiological investigation shows our HP infection rate is 40%-90%, an average of 59%, which among the lowest is in the region of Guangdong Province, as 42%, and among the highest group is in Tibetan Lama of 90%.About 80% of patients with Hp are unconscious of the disease even in suffering or in dangerous of possible transformation into gastrointestinal cancer in the future, as it has no obvious symptoms. Western exam method is accurate, but expensive, time consuming and less easy to carry out. This study designs the clinical trial on auricular diagnosis, by inspecting, palpating and electric examining the auricular to achieve the purpose of auxiliary diagnosis, which can assist in screening Hp patients with low cost, and provide further suggestions on diagnosis and treatment in its early stage.Objectives:this study designs Helicobacter pylori infection as the major diagnostic criteria. By ways of aural inspection, palpation, and potential detection, this study establishes a model to assist in preliminary diagnosis and screening of HP infection.Methods:From June 2009 to March 2010, every patient entered the cooperation clinics, after signing the consent forms will be assigned into case group (HP positive) or control group (HP negative) by criteria of inclusion and exclusion. The study collected 101 valid cases for case group (Hp positive), and 91 valid cases for control group (Hp negative). According to the international standard figure for auricular points, the study collected data of aural inspection, palpation, and potential detection.Results:this study employed the logistic regression to filtrate significant variables, then brought those variables into the K-th nearest neighbor discriminant analysis, using method of enter independent together, to establish a discriminant model of detecting HP infection. The model utilized information of patient's age, and pain sensation (yes or no) of auricular points of stomach, heart, subcortical, and urethral. The results show feasibility of auricular diagnosis on HP infection with diagnostic specificity of 97.03%, and sensitivity of 98.90%.Conclusion:This study demonstrates high efficiency of detecting HP infection through auricular diagnosis. Auricular diagnosis is able to apply to screening or preliminary diagnosis of HP infection with characteristics of non-invasive, low-cost, easy to operate, and easy to promote.