Chinese Medicine Treatment Of Melasma Literature Evaluation And Clinical Research

Objective1 Chinese medicine treatment of melasma by systematic evaluation of literature to objectively assess the current clinical applications of scientific research methodology and the overall level of clinical research as well as to provide reference.2 By means of treatment for melasma patients with syndrome differentiation to demonstrate the clinical efficacy.Methods1 Literature are searched from PubMed Result NCBI database during the period 1989/01-2009/03. Evaluations are based on clinical epidemiology/DME methodological principles and methods, and accepted by "Traditional Chinese medicine literature of systematic evaluation of job handbook". The norms included in the study of the methodological quality according to Cochrane Center Improved quality evaluation of literature JADAD scoring method are using Excell evaluation form to establish a database and statistical R2.11.0 (Rmeta analysis softwave) by (http://www.r-project.org/) software to analyse.2 Patients are included by the Western and TCM diagnostic criteria with chloasma, according to TCM syndrome differentiation and treatment of typing, using prospective clinical trial design their own matching design approach, using paired T-test to compare group differentiation between before and after treatment, besides, using R2.11.0 software to carry out statistical analysis processing. Results1 A total of 1538 documents are retrieved from PubMed Result NCBI database, and 95 randomized controlled trials (RCT) are included. Published literature were increased year by year, the efficacy of medical treatment of the melasma is a evidence-based medical evidence, but the vast majority of literature are obvious shortcomings in the experimental design, statistics and reports.2 Patients are treated on TCM syndrome differentiation and treatment for 4 months,7 patients (23.3%) are cured,21 patients (70%) are effective, and only 2 (6.7%)of them are invalid. Patients are all evaluated with lesions of the area integral and pigment level, after two courses of treatment, scores are significantly reduced, and subvalues are statistically significant (P＜0.05).Conelusion1 Research literature on Chinese medicine treatment of melasma in the may be restricted by the level of past clinical research and traditional Chinese medicine theory, objective and standardized aspects of the study inadequate methodological quality of clinical trials are still to be improved.2 Clinical efficacy of Chinese medicine treatment on melasma is objective, and discomfort of patients with symptoms and quality of life can be significantly relieved.