| Objective:To evaluate the efficacy and safety of Traditional Chinese Medicine with tonifying Qi and activating Blood for acute cerebral hemorrhage.Methods:According to the methods of systematic review recommended by the Cochrane Collaboration, we collected the randomized controlled trials (RCTs)about tonifying Qi and activating Blood for acute cerebral hemorrhage through the electronic and manual search, and the deadline was December2011, Two reviewers selected studies, assess quality of studies, and studies, extracted data independently. Meta-analysis was to be performed with the Revman5.1.Results:Total into ten randomized controlled trials, are Chinese, all press the definition of Traditional Chinese Medicine with tonifying Qi and activating Blood evaluation,10test scores are for C level of quality. Only a fatality rate of12weeks, stroke integral drop value influence and evaluate NIHSS classification, the rest of the most studies to explore the effect not only on the evaluation.(1) Dring treatment of mortality, three studies reported:A.3studies reported tonifying Qi and activating Blood circulation to end herbal treatment (14d) the case fatality ratio of influence,[OR0.59,95%CI (0.24,1.46)] difference was statistically significant. B. One studies reported tonifying Qi and activating Blood to end herbal treatment (28d) the case fatality ratio of influence,[OR0.23,95%CI (0.02,2.15)] difference was statistically significant. C. Otherwise1studies reported tonifying Qi and activating Blood to end herbal treatment after12weeks the case fatality ratio of influence,[OR0.87,95%(CIO.36,2.13)] difference was statistically significant.(2) Neural function defect classification is divided into four studies the influence of the report:A. Two studies in patients with acute cerebral hemorrhage of neural function defect classification (14,15d),[OR8.26,95%CI (2.79,24.45)] difference was statistically significant (the treatment group than in control group). B. Two studies in patients with acute cerebral hemorrhage of neural function defect classification (21d),[OR3.80,95%CI (0.99,14.53)] difference was statistically significant (the treatment group than in control group). C. A study of patients with acute cerebral hemorrhage neural function defect classification (28d),[OR3.76,95%CI (1.04,13.65)] the difference was statistically significant (the treatment group than in control group). D. With the above five for patients with acute cerebral hemorrhage of neural function defect classification (14,15,21,28D) study,[OR5.27,95%(CI2.61,10.64)], the difference was statistically significant (the treatment group than in control group).(3) One study end index for 《the stroke diagnosis and the curative standard (try out》 in the conventional treatment based on tonifying Qi and activating Blood after Chinese herbal compound (14d), patients with acute cerebral hemorrhage outcome (OR3.99,95%CI (1.29,12.37)], the difference was statistically significant (the treatment group than in control group).(4) One study result set in1986index of 《the stroke, curative effect of traditional Chinese medicine diagnosis evaluation standards》 in the conventional treatment based on tonifying Qi and activating Blood after Chinese herbal compound (30d), patients with acute cerebral hemorrhage outcome (OR3.85,95%CI (1.13,13.09)], the difference was statistically significant (the treatment group than in control group).(5) One study end indexes of the state administration of traditional Chinese medicine for 《The traditional Chinese medicine diagnosis and stroke curative effect evaluation standards》 in the conventional treatment based on tonifying Qi and activating Blood after Chinese herbal compound (30d), patients with acute cerebral hemorrhage of comprehensive curative effect evaluation,[OR6.43,95%CI [(1.26,32.83)], the difference was statistically significant (the treatment group than in control group).(6) One study end with reference to 《The Chinese herbal medicine new medicine clinical research guiding principle》, to acute cerebral hemorrhage patients of the long-term (12weeks) stroke integral drop value affect curative effect classification judgement,[0R4.22,95%CI (1.41,12.66)], the difference was statistically significant (the treatment group than in control group).(7)3studies end for governance index neural function defect scale comparison, based on routine treatment application tonifying Qi and activating Blood TCM compound are in for21days,28days neural function defect scale compared.[MD=4.96,95%CI (6.49,3.43)], the difference was statistically significant (the treatment group than in control group). (8) One study for the end index:tonifying Qi and activating Blood TCM compound21days after treatment, and patients the ability of living condition (evaluating the degree of invalid),[MD=1.06,95%CI (1.93,0.19)], the difference was statistically significant (the treatment group than in control group).(9) One study for Glasgow-Pittsburgh end index coma assessment scale state of consciousness, tonifying Qi and activating Blood:herbal treatment30days after scoring more,[MD=4.25,95%CI (0.18,8.68)], difference tip was not statistically significant.(10) One study to assess Brunnstrom end index method of operation function, tonifying Qi and activating Blood:herbal treatment for30days movement function classification comparison,[MD=1.11,95%CI (0.20,2.02)], indicates a statistically significant difference (the treatment group than in control group).(11) One study for treatment after14days ending index points to change the situation is more, with reference to 《the stroke disease diagnosis and treatment standard (try out)》 for treatment after change the situation is more points,[MD=2.17,95%CI (9.71,5.37)], difference tip was not statistically significant.(12) One study reported the end:tonifying Qi and activating Blood herbal treatment according to the treatment group, in treatment (12weeks) NIHSS scores after comparison,[MD=2.92,95%CI3.50to2.34)], indicates a statistically significant difference (the treatment group than in control group).(13) One study for the treatment of the10days after ending index edema absorption rate change situation comparison,[MD=0.08,95%CI (0.04,0.13)], indicates a statistically significant difference (the treatment group than in control group).(14) One study end for tonifying Qi and activating Blood index herbal group, the treatment of28days around the hematoma volume variation edema comparison,[MD=3.80,95%CI (7.66,0.06)], indicates a statistically significant difference (the treatment group than in control group).(15) During treatment the comparison of the hematoma quantity, there are four research report:A.3studies end for the treatment of the index14,15days after the comparison of the hematoma quantity,[MD=4.67,95%CI (10.78,1.43)], not significant differences. B. A study for the treatment of the21days after ending index hematoma volume of comparison,[MD=4.32,95%CI (5.17,3.47)], the difference was statistically significant (the treatment group than in control group). C. A study for the treatment of the end index28days the comparison of the hematoma quantity,[MD for-2.83,95%CI (6.68,1.02)], the difference was statistically significant (the treatment group than in control group). D. A combination of the five:use tonifying Qi and activating Blood, researchers report over time to treatment were (14D,15D,21D, and D) in patients with acute cerebral hemorrhage of hematoma quantity comprehensive comparison of [MD=4.33,95%CI (7.61,1.05)], the difference was statistically significant (the treatment group than in control group).(16)2studies end for tonifying Qi and activating Blood, index:herbal treatment21days after15, the comparison of the hematoma absorption rate,[MD=0.19,95%CI (0.01,0.39)], not significant differences.(17) a research outcome for hematoma completely absorbed, index edema completely resolve, the benefit of traditional Chinese medicine treatment method of tonifying Qi and activating Blood, after (14days) and control group for comparison,[OR3.24,95%CI (0.85,12.36)], not significant differences.Conclusion:This paper defined tonifying Qi and activating Blood TCM compound in the short term to reduce the acute cerebral hemorrhage in recent case fatality ratio and the long-term impact is not clear, the analysis after evaluation were not significant, failed to tip the qi and activate blood circulation:herbal treatment can reduce the mortality of patients with acute cerebral hemorrhage. To improve acute cerebral hemorrhage neurologic deficits and reduce hematoma quantity, reduce cerebral edema and overall outcome, have certain statistical significance, suggests that the benefit qi and activate blood circulation herbal therapy in patients with acute cerebral hemorrhage, have certain curative effect and related value there. Due to the limited number of samples and curative effect evaluation index is differ, but for the survival rate and the influence of the neural function defect is not clear. So beneficial qi and activate blood circulation TCM compound in acute cerebral hemorrhage during the application, still need to increase the scale, improve quality, and follow-up time enough randomized study, for cerebral hemorrhage acute period, tonifying qi and blood use method using the related benefit qi and activate blood circulation TCM compound to deliver more valuable evidence and further evaluation and confirmed. |
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