Study On The Effects Of Artery Elasticity Of Spontaneous Hypertension Rats With The Treatment Of Tonifying The Kidney Qi

Objective: Discuss the effects on artery elasticity (pachynsis, funciton of blood vessles) and process of hypertension with the treatment of tonifying the kidney qi, and reveal the possible mechanism of its function.Method: Base on the initial study of the research project of"Study on treating hypertension of the aged with the treatment of tonifying the kidney qi", discuss the functional mechanism of the treatment of tonifying the kidney qi from 3 aspects, such as study on theory, documental commentation and experimentation. Choose spontaneous hypertension rats as models, seperate them randomly into 4 groups by stratification-group procedure, such as negative control group (model group), group of taking Yishenjiangya Mixture with high or low dose and positive control group (lacidipine group). Give them relevant medicines (Yishenjiangya Mixture or lacidipine) by intragastric administration for 8 weeks. Detect the systolic pressure and heart rate before and after administration, detect NO by Nitrate reductase method, detect ET by radioimmunoassay. Observe the alleosis of aorta thoracalis, stain the collagens of the Aortic by masson trichrome coloration and Sirius red staining method, stain Colâ… and Colâ…¢by immunohistochemical staining method (SP method ), calculate the contents of the collagens.Results: Yishenjiangya Mixture can obviously decrease the systolic pressure and heart rate of the spontaneous hypertension rats, adjust vasoactive substance, heighten the contents of NO, lower ET level; lower the contents of collagen in arteries, decrease the positive express; lower the contents of Collagenâ… andâ…¢, decrease the possitive express.Conclusion: The treatment of tonifying the kidney qi can control the blood pressure placidly, treat and defer the developmental process of SHR blood pressure. It can heighten the contents of NO, lower ET level, so that can lower the contents of collagens in arteries, improve the artery elasticity and abnormal diastolic- contractive function. Taking tonify-the-kidney-qi as the treatmental principle for hypertension of the aged is an effective therapy to accord the pathogenesis.