The Efficacy And Mechanism Study Of Yinlanyigan Granules Preventing And Treating Acute Drug-induced Disease

Objective: To observe the effect of Yinlanyigan granules on the Acute Drug-induced Disease and explore the mechanism of it. Methods: Clinical study :61 patients with Acute Drug-induced Disease were divided into two groups at random:the treatment group and the control group. The treatment group was given Yinlanyigan granules,the control group was given Silybin Meglumine Tablets. Observe the clinical efficacy. Experiment study: 72 normal KD mice were randomly divided into 6 groups. The Acute Drug-induced Disease rat Model were established with AP. Observe the decoction effects of Yinlanyigan granules on ALT, AST, TNF-α, SOD , GSH, CYP2E1, fat content and cell construction. Results: The treatment group's main effective rate of the syndrome of TCM,the results of liver function test are better than the control group's. Yinlanyigan granules can improve SOD and GSH, reduce TNF-αand MDA, restrain the expression of CYP2E1, correct lipid metabolism mess. Conclusions: Yinlanyigan granules is a effective drug of treating Acute Drug-induced Disease, it can moderate clinical symptom, alleviate the patients'sufferings rapidly. The mechanism contains improving SOD and GSH, reducing TNF-αand MDA, restraining the expression of CYP2E1 and correcting lipid metabolism mess.