Lee Jaundice Granules Of Drug-induced Liver Injury In The Endotoxemia

Objectives:To explore the efficiency of Lidankang Keli in treating Drug-induced liver injury.Methods:eighty healthy Winstar mice were divided into six groups of twleve as following:normal control group,model control group,high-dosage treatment group,middle-dosage treatment group,low-dosage treatment group,Huganningpian positive control group.Expect group one,the other five groups were injected Paracetamol Suspension (150mg·kg^-1) in the abdominal cavity of the mice everyday.Three days later,mice of group three,group four and group five were forced to take the Lidankang Keli directly intostomach respectively according to the dosage of 223.4mg /(kg·d),111.7mg /(kg·d),58.9mg /(kg·d)).Mice of group six were forced to take Huganningpian aqueous solution(22.75mg/kg). Mice of group one and group two were fed the same volume of distilled water.Keeping these actions once per day for two weeks.After the last time of giving medicine,mice of each group were forbidden to eat for twelve hours.Then took the blood sample through the mice's abdominal aorta.Through the examining on the Drug-induced liver injury mice's the function of on protecting liver,lowering GPT and preventing liver damage.Conclusion:Each dosage of Lidankang Keli can lower the rising of the mice's ALT,AST, ALP,GGT,TBIL caused by Paracetamol Suspension,and can rise the mice's falling of ALB, A/G caused by Paracetamol Suspension.The curing intensity id related to concentration and the statistics shows that the high-dosage treatment group has better curative than the others. All of above shows that Lidankang Keli has an good effect on curing Drug-induced liver injury.