Theoretical, Ciinical And Experimental Research About The Effects Of Postponing Ageing With The Symptom Of Deficency Of Qi And Yin By The Means Of Replenishing Yin, Complementing Qi And Clearing Blood Stasis

Our country has already become a society of decrepitude, and there will be more and more aged people quickly. In order to guarantee the health of the aged and lighten the burden of the family and society, the research about postponing ageing should be carried out urgently. The modern medical science hasn't given a hard conclusion about the reason and mechanism of ageing. Although the present means of postponing ageing are effective to some extent, the oneness of mechanism can hardly keep coincident with the character of multi-systems and multi-levels when decrepitude happens. In contrast, traditional Chinese Medicine can make its way in many different terms with little toxicity. In this research, we find that patients with the type of deficiency of kidney is very common, but there are still many patients with the type of deficiency of QI and YIN, and the type of blood stasis is also very common. So, we consider that the means of replenishing YIN, complementing QI and clearing blood stasis will be more effective in postponing ageing. Therefore, we carried out this research of probing into the elementary theory, clinical effects and probable mechanism of t postponing ageing by the means of replenishing YIN, complementing QI and clearing blood stasis, hoping to bring a new way to prevent or postponing ageing.In the section of theoretical research, according to the past recordation about decrepitude, combining domestic and international researchers' reports and the tutor's clinical experience, we think that the traditional theory of single internal organs ageing can not explain the essence of ageing, and the real reason of ageing is deficiency of QI and YIN or blood stasis. We think the usual causes of ageing are: lack of the inborn, deficiency of original QI; carelessness about meal, dysfunction of spleen; the feeling ambition not hence, the blahs HUO hurting YIN; too much labor, consuming blood and YIN; inside blood stasis; " attack of outside XIE, consuming inhere QI and YIN. All theses factors can affect the body in terms of QI, YIN and blood stream, and then lead to the type of deficiency of QI and YIN or blood stasis. The mean TCM mechanism includes: the weakness of body QI leads to the five internal organs getting weak; deficiency of YIN causes ill HUO, and the body get lack of nutrition; blood stasis bring retardarce to JINLUO; Body QI gets weak and XIE occupies the body, and then the two of them turn into each other. Single type of deficiency of QI or YIN or blood stasis is not very popular. In most circumstances, they come forth together and turn into each other. The deficiency of QI and YIN can lead to the production of JING, blood and liquid getting down. And then the five internal organs become lack of nutrition. At the same time, the deficiency of QI and YIN can also lead to blood stasis. which will worsen the condition of decrepitude. Deficiency of YIN is the basic disease, and blood stasis can also consume liquids of body, which can worsen the condition of deficiency of YIN. The blood stasis will result in dysfunction of the internal organs, which leads to the production of liquids slow down. As a result, the insufficiency of liquids will get worse. Blood stasis can often hurt the JINGLUO and lead to bleeding, which will do harm to YIN and blood in further. Blood stasis can also result in disorder of body QI movement, then, the liquid can not be transported to the body, which leads to harm of YIN and liquids. Therefore, the deficiency of YIN can lead to blood stasis, and blood stasis can worsen the deficiency of YIN. The two of them can affect each other. The deficiency of QI and YIN can result in many kinds of senile diseases. As a result, the senile diseases can do harm to the body of patients, which can cause the insufficiency of body QI, And then, the speed of ageing gets higher, and a bad recycle comes into being. In the process of ageing, there are mechanisms such as the imbalance of YIN and YANG, scarcity of nutrition in internal organs and block of JING LUO, which are caused by deficiency of QI and YIN and blood stasis. Otherwise, internal HUO and blood stasis are very common in ageing body. Therefore, adjusting YIN and YANG, compensating the insufficiency, clearing blood stasis and other nosogenesis are all important for postponing ageing. The main method s are as following: reinforcing body QI, boosting up the ability of immunity; replenishing YIN and liquids, but avoiding blocking stomach function; facilitating blood stream, avoiding hurting body; getting rid of internal RE, defending YIN and liquids, and eliminating fret. During the course of choosing herbs, we must pay attention to the tastes and character. We also emphasize the application with other therapeutic method to eliminating XIE according to syndrome differentiation to defend the healthy energy.In the clinic research, we observed the therapy effects of replenishing YIN, complementing QI and clearing blood stasis on ageing patients. Blank collate group was set as the contrast. The observation is the score of decrepitude symptoms which includes: forgettery, loving sleep, easy tired, respond muff, waist backache, catching cold easily, sudation, night sweat, breathing hard, heart-throb, losing hair, anorexia, thick stool, dry and hard stool, cold-blooded, limb cold, much night urine, aching waist knee, body numbness, and so on. The differences between the two groups in the testing items which includes SOD, NO, Cu²⁺, Zn²⁺, urine-MALB. bloodβ₂-VMG, urineβ₂-MG, PBG, blood lipid are also observed. In order to test the safety of the herbs, we test some other items, the results manifests: routine examination of blood, urine and sed, ECG, liver function, renal function and ultrasound B were studied before and after treatment. The result indicates the general effective rate is 92.9% for the therapeutic therapy group and 10.3% for the control group. There is obvious difference between the two groups (P<0.05) for the item of effective rate . As for the score of symptoms of forgettery, loving sleep, easy tired, respond muff, waist backache, catching cold easily, sudation, night sweat, breathing hard, heart-throb, losing hair, anorexia, thick stool, dry and hard stool, cold-blooded, limb cold, much night urine, aching waist knee, body numbness ,there is very obvious difference between the two groups(P<0.05) . The scores of symptoms are statistically different for the therapeutic group between before and after therapy (P<0.05) .The scores of symptoms are statistically indifferent for the control group between before and after observe (P>0.05) . There is obvious difference between the two groups for the item of SOD, urine-MALB and PBG(P<0.05) ,in which the probable mechanism of postponing ageing exists. There is no obvious difference between the two groups for the item of NO, Cu²⁺, Zn²⁺, bloodβ₂-VMG, urineβ₂-MG and blood lipid (P>0.05). The result indicates that taking the SHENHUANG powder is helpful for the decrepitude symptom. The most obvious function lies in the to the clinical symptoms and living quantity. Patients' SOD of low level value also gets obvious improvement, which show that the SHENHUANG powder can raise the serum SOD level and then strengthen the anti- oxidizing ability of body. The PBG of the therapeutic group gets down statistically obviously. There is obvious lowness between the two groups in terms of urine-MALB. At the under medical treatment, we did not discover any bad reaction. The safety of this method is credible. Conclusion: The means of replenishing YIN, complementing QI and clearing blood stasis can effectively improve the clinical symptoms, and can also improve some experimental items. The means of replenishing YIN, complementing QI and clearing blood stasis is a very effective way of postponing ageing. At the same time, the means of replenishing YIN, complementing QI and clearing blood stasis is one of the most important TCM methods which improve main symptoms of modern decrepitude patients.In the experimental research, we observed the therapeutic effects of SHENHUANG powder in terms of improving anti-freeradicals ability in ageing rats model induced by D-gal. We set SHENHUANG powder high-dose group, SHENHUANG powder low-dose group, positive control group, ageing passive group and young and healthy passive group. The change happened in the items of SOD, NO, GST,GSH-PX,CAT and T-AOC are recorded, which has some correlation with the free radicals metabolization. It indicates that there is no obvious statistic difference between the therapeutic group and the control group in terms of SOD, NO, GST, GSH-PX and CAT (P>0.05 ) . There is obvious statistic difference between SHENHUANG powder group, positive control group and ageing passive group (P<0.05), which indicates SHENHUANG powder is similar with the positive drug in terms of improving the items of SOD, NO, GST, GSH- PX and CAT. It is confirmed that SHENHUANG powder can activate enzymes of anti- oxidation, speedup the disassemble of freeradical, improve the ability of anti- free radicals. It is also prompted that improving the ability of anti- free radicals is one of the mechanisms of SHENHUANG powder postponing ageing.In fine, the means of replenishing YIN, complementing QI and clearing blood stasis has been proved to be effective for postponing ageing, which gives a strong support to the theory of postponing ageing by the means of replenishing YIN, complementing QI and clearing blood stasis. Some of the modern mechanisms of postponing ageing by SHENHUANG powder are revealed .At last, we consider that therapy of TCM is the main way of postponing ageing, and the means of replenishing YIN, complementing QI and clearing blood stasis is one of the basic therapy of postponing ageing.