Rattus Hedyotis Alkali

In this paper, the natural product Chrystocine was studied thoroughly, including the total synthesis, relation between structure and activity and the solid phase synthesis of carbolines.I. To complete the total synthesis, several routes have been proposed. In the end, Chrystocine was obtained successfully using two Sharpless AEs as the key steps. The spectral data and [a]_D²⁰ is in agreement with that of the literature. Thus the absolute configuration of the natural product is fixed to be R, R.The synthesis process was shown on Page 3.II. On the basis of the total synthesis, the relation between structure and activity was studied. A series of analogues containing the tetrahydrogen furan core were synthesized.The structure of the analogues was shown as following:R₁=OH, OBn.R₂=H, OMs , piperazine, piperidine, 4-benzoylpiperazine, 4-benzyl- piperazine, 4-acetoylpiperazineThe absolute configuration of the carbon 1,2,3 could be RSS, RRR, SSS or SRR.The general pharmacological screening is in progress.