| Depression is a psychosis, which is characterized by various manifestations of affective disorder. It affects patients'working,learning and living so that they have difficulty adapting themselves to society,even develope suicidal behavior at last. With intense social competition and fast working pace,more and more people will feel tensive,exhausted and melancholy. Incidence rate　of depression will show an upward tendency.Furthmore,relief of depression is related to the rehabilitation of body disease. Psychopathology of depression is not known. Treatment on depression that is based on the hypotheses has a variety of defects. Today, the research is focused on the pathogenesis of depression and the new drugs that are effective and have fewer side effects. On the basis of the traditional theories,traditional Chinese medicine(TCM)have played more and more important role in treating depression. Classical prescriptions have showed a satisfactory prospect on treating depression. The systematic research was carried out on studying Zhonging's principle of formation of prescription and TCM's theories of stasis combining with contemporary theories,experimental and clinical results of TCM and Western medicine.Those will be of great importance to develope classical prescriptions and improve the effect of TCM on treating depression and understand the mechanism of treating depression of classical prescriptions.The principal contents and conclusions in this study:1 To systematically analyze experimental and clinical literatures and discuss the methods of pharmacological experiment of antidepressants suit for the traditional Chinese compound prescription and the principles of formation of prescriptions with antidepressant effect.Nowadays,converging lines of evidence have led us beyond monoaminergic synapse for strategies to improve antidepressant,many studies have provide an entirely new set of potential therapeutic targets, including neurotransmitters and its receptors,key agents among cell signal transduction pathways,neuropeptides,neurotrophic factors,NMDA receptors,HPA and HPT axises,cytokines。These have revealed that antidepressants may elevate the level of monoamine neurotransmitter and have an effect on receptors and its transduction to induce expression of certain genes and recover neural function in CNS.Hormones and cytokines are relative to CNS,so antidepressants should be studied from various targets ,different systems and its adaptive regulation.The compound prescriptions of treating depression can be divided into eight kinds according to their effect,including prescriptions of dispersing depressedliver-qi to relieve emotional depression,tranquilizing the mind and inducing resuscitation,regulating the liver and spleen,resolving phlegm and regulating the flow of qi,invigorating the heart and spleen,nourshing liver and kidney,nourishing yin to clear away pathogenic fire,promoting blood circulation and removing blood stasis. There are eleven kinds of drugs in prescriptions,including drugs of replenishing qi and reinforcing the spleen,tranquilizing the mind,regulating qi,tonifying blood or promoting blood circulation,resolving sputum,clearing away the heat,tonifying the kidney,inducing resuscitation,nourishing yin,calming the liver,removing retention of food. There are some common principles in these prescription such as tranquilizing the mind, reinforcing the spleen and dispersing depressed liver-qi.These therapeutic methods are adaptive to depression according to its symptoms. There are 1/5 in antidepressant which is based on classical prescriptions. The drugs of SiNi Powder (SNP) show higher frequency in antidepressant prescriptions at present. Analyses have revealed that classical prescriptions have the advantage of treating depression.The screening test and development procedure will be shorten, because the compound prescriptions have been verified by clinical treatment before pharmacological experiment.The manners of action of prescription is coincident to strategies of antidepressan... |
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