| According to the survey of epidemiology the incidence rate and the death rate of asthma is increasing since 1960s. Together with the long course and the difficulty of cure, asthma brings heavy economic burden to society. So it attracts much attentions of countries around the world.Asthma is a kind disease of chronic airway inflammation, and airway hyperreactivity (AHR) and reversible airstream restriction are related to airway inflammation closely, and glucocorticoid is the principle choice for asthma treatment. However, many recent researches suggest that there is abnormal GCR (glucocorticoid receptor) level including quantity reduction and functional defect in asthma patients with and without glucocorticoid treated, and reason of abnormal GCR standard is still confirmed. It is truism that glucocorticoid will lead to further descent of GCR standard. So, it is urgent to seek theraputic drugs for asthma in essence not simply improving asthmatic symptom.In the opinions of my advisor professor Wu Weiping, the position of asthma is the lung, it is related to the liver closely. "Wind", "phlegm", "Qi", "stasis", "asthenia" are the main pathogenesis of asthma, and disharmony of the liver and lung, disturbance of Qi and blood is the key point of pathogenesis. So regulate the function the liver and the lung, adjust Qi and blood is in common use when treat asthma, and it's effective in clinic. The complex prescription of traditional Chinese madicine梄iao Chuan King granule created on the basis of the theory and has been used in clinic for many years shows definite therapeutic effects. This prescription gained good effects not only in mild and moderate asthma but also in severe glucocorticoid dependend asthma by reducing the oral dosage of glucocorticoid.The purpose of this study is finding out the pharmacological mechanism of Xiao Chuan King granule treating ashtma. During the experiment, we repeat animal models of allergic asthmatic rats by ovalbumin mixture intraperitoneal injection, ovalbumin acting as allergen, aluminium hydroxide and bordetella pertussis acting as immune adjuvent. Using Bu Shen Fang Chuan pill as the control medicament, search possible pharmacological effect of Xiao Chuan King granule on GCR.1 observing asthmatic rats' common state, inspecting pulmonary function of asthmatic rats, observing morphology of pulmonary tissues under microscope suggest, that the asthmatic rats appeared typical symptoms of asthma including fast respiratory frequency > lower pulmonary ventilation function and typical pathologic changes of lung tissues. Xiao Chuan King granule can (1) effectively improve rats' asthmatic symptoms. (2) lower asthmatic rats' respiratory frequency. (3) improve pulmonary ventilation function by reducing resistance of expiration and resistance of inspiration, rising pulmonary compliance, rising maximum ventilatory volume, appreciably rising 0. 3FEV% , appreciably rising peak expiratory flow and appreciably rising forced expiratory flow 25% -75%. (4) improve asthmatic rats morphological abnormal by decreasing lymphocytic cells and eosinophilic granulocytes soakage.2 Examining asthmatic rats' IL-4 level in serum and BALF suggest, that asthmatic rats' IL-4 level is increasing in serum, especially in BALF, and Xiao Chuan Ning granule can reduce the IL-4 level in serum and in BALF.3 Examining GCR maximum specific binding in asthmatic rats' lung tissues, GCR mRNA expression and cortisol concentration in serum suggest, that GCR maximum specific binding reduce obviously as well as GCRmRNA expression, while cortisol concentration in serum reduce obviously. Xiao Chuan Ning granule can increase GCR maximum specific binding reduce obviously, GCRmRNA expression, and cortisol concentration in serum.4 By intervented with dexamethasone, asthmatic rats represent typically asthmatic appearance later but badly little by little, respiratory frequency becoming fast obviously, pulmonary ventilation function reducing and lung tissues appearing typical pathomorphologic changes. Xiao Chuan...
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