Intestinal Capsule In The Treatment Of Ulcerative Colitis

According to the theory of traditional Chinese medicine about the relationsbetween Zang and FU.We used the capsule ChangAn (CAC)which can invigorate the spleen to benefit the lung and eliminate phlegm to resist diarrhea with astringents to treat ulcerative colitis (UC). All of these studies were carried out both in the clinic and the animal experiments.REVIEWA great deal of literature showed that the traditional Chinese medicine(T.C.M)therapy was eutherapeutic for UC.But its principle of treatment was limited to some extent.So to study the diagnosis and treatment rule of UC on the basis of traditional method was very necessary.which was helpful to perfect the diagnosis and treatment systerm of UC.CLINICAL STUDYThe clinical studies showed that CAC could make the clinical symptomsof UC patients improved and accelerate ulcer healed over.Among the 62 cases treated with CAC for 3months.the clinical symptoms, the colonofiberscope appearance and the pathological changes had been improved obviously. The effective ratios were 91.93%, 80.64%, 83.87% respectively.and they were signficantly higher than that of the control.the pill BUPIYICHANG(BPYCP) (P<0.05) The studies also indicated CAC could adjust human immunity action.which made many cell mediatedimmunity and humoral immunity signs better. Besides of this .this medicine also could promote the activity of superoxide dismutase (SOD) and lower that of the lipid peroxidation(LPO).lts action was superior to the control, BPYCP (P<0.05).ANIMAL EXPERIMENTThe animal experiments showed CAC could excellently treat the rat' sEUC which was induced by local stimulation and immunity methods .Not only could the medicine improve the activity of SOD,lower that of LPO in rat' s blood ,but also adjust the content in blood serum of Ig ,CIC,IL-2,TNF-a , NO to make them better .After the treatment, the rat' s weight and their serum proteins were markedly higher. Its action was superior to the control,BPYCP(P<0.01-0.05). Moreover, the primary research was carried out about the theraputic mechanism of CAC and the accordance from which the prescription formed.