Experimental Study Of KLN Le On It' Capsus Anti-tachyarrhythmia Effect

Objective First, copy goat acute stress tachyarrhythmia model, to carry outexperimental study of KLN capsules' against stress-induced ventricular arrhythmiasfunction.Second,To carry out the KLN capsule anti-tachyarrhythmia pharmacodynamicevaluation, to provide experimental basis for clinical and research work of the KLNcapsule.Methods The experimental animals were randomly divided into model group, thepositive control group and the KLN high, medium and low-dose group. First,Carry outexploratory research on model of goat acute stress arrhythmias using both normal ECG andHolter. Observe the goats' heart rate,arrhythmias and other relevant indicators before andafter stress. And do the effective observation of KLN capsule on anti-stress-inducedarrhythmias on goats. Second, To establish barium chloride, aconitine induced ratarrhythmia model and wow bar-induced guinea pig arrhythmia model, and observe theduration, the required barium chloride and other drugs dose of these three models.Results First,After the study of the goat model of stress, only sinus tachycardia witharrhythmia were found, but ventricular premature beats and other ventricular arrhythmiasfailed; the KLN capsule can significantly reduce heart rate on sinus tachycardia model ofacute stress, has significant difference (P <0.01) compared with the model group. After theintervention of KLN high, medium dose group and the metoprolol group, the heart rate hasbeen close to normal. Second,Compared with model group, the KLN capsule delayedthree models arrhythmia time, shorten the duration, and a increase in the dose of therequired barium chloride and other drugs appear. Compared with propafenone group, KLN capsule high dose and medium dose has the same overall efficacy. There are significantdifferences in the efficacy of low-dose group (P <0.01). Compare each KLN group,high-dose and medium dose group have no significant difference (P>0.05), both of whichsignificantly better than the low dose group (P <0.01).Conclusion First,According to the reported literature, through a rigorous replicationof the model and improvement programs, yet can not produce goat acute stress-inducedventricular arrhythmia models.Second,KLN capsule is effective on goat stress-induced sinus tachycardia,with thedose-effect relationship.Third,KLN capsule is effective on anti-barium chloride,aconitine,and ouabaininduced arrhythmias in guinea pigs and rats,and has a significant dose-effect relationship.