The Clinical Research Of Chronic Hepatitis B Treated With Qizhufang

Objective:To observe the effect of QIZHUFANG in treating chronic hepatitis b curative effect, including symptoms, positive syndrome improved and liver function and hepatic fibrosis of chronic hepatitis B, to try looking for treating method of traditional Chinese medicine.Methods:from2009January to2011December, from Jiangsu Province Traditional Chinese Medicine Hospital, Changzhou Third People's Hospital, Nanjing Jiangbei hepatitis outpatient service people's Hospital, Nantong Third People's hospital. Patients diagnosed with chronic hepatitis B were classified as observation objects, randomly divided into treatment group and control group,120cases in each. The test group,lto2times daily. Control group:Lamivudine, oral,1capsules each time,1timesldays. Continuous medication for30days. After the end of treatment were followed up for6months. Clinical trials after the end of treatment, according to clinical routine method. Outcome measures included (1) the clinical symptoms, chest pain, loss of appetite, fatigue was observed using integral method of recording. Every4weeks a record1time.(2) laboratory examination, liver function indices:ALT, AST, ALP, r-GT, TB, Al, G, around1times each check; etiological indexes (HBsAg, anti HBs, HBeAg, anti HBe, anti HBc, HBV-DNA), the examination1times every12weeks. Blood, urine, stool, electrocardiogram, renal function (BUN, Scr), before and after each treatment were examined1times. Descriptive statistical analysis, qualitative index using frequency table, percentage or proportion description; quantitative indicators to mean±SD. Two groups of comparative analysis, qualitative data by using the chi-square test. t test.Results:the treatment group70cases male,50female, mean age of38.44±9.06years; the control group76cases male,44female, mean age of39.28±8.70years two groups in gender and age have no significant difference (P>0.05). The treatment group of120cases of chronic hepatitis B patients with mild in65, moderate in55; the control group of120cases patients of mild chronic hepatitis of62, moderate in58. The severity of two groups of patients is of no significant difference (P>0.05). Two groups of patients before and after treatment with integral inspection by T, the treatment group had different degrees of improvement in symptoms (fatigue, chest pain, anorexia, abdominal distension, jaundice of the P values were0,0.003,0.002,0.002,0.004); the control group fatigue, jaundice also have improved (P=0.014,0.027); compared with the control group, Qi beads can significantly improve patients with chest pain, anorexia symptoms (P=0.025,0.014). Two groups of liver function in the treatment of ALT, AST, GGT, ALP were significantly improved. Two groups of patients before and after treatment, liver fibrosis indexes (hyaluronic acid (HA). laminin (LN), type IV collagen (IVC)) were improved to different degree. The study of two groups of patients with HBeAg, HBVDNA changes are similar, the chi-square test, no significant difference. The treatment group120cases. complete response in22cases (18.3%), partial response in44cases (36.7%), no response in54cases (45%), the total effective rate was55%; the control group of120cases,26cases of complete response (21.7%), partial response in42cases (35%),52cases (43.3%)., the total efficiency of56.7%, two groups of overall efficacy comparison, the difference was not statistically significant. Comparison of curative effect of two groups, upon examination, x2=0.015, P=0.352. Before and after treatment, renal function, blood routine electrocardiogram safety indicators have no obvious abnormality.Conclusion:QIZHUFANG can improve chronic hepatitis B patients with symptoms, signs and liver function, there are certain antiviral effect, the mechanism may be the support body, clearing dampness heat Stasis Toxin, it is worth studying further.