The Chinese medical science has a long stream. The traditional Chinese medicine (TCM) theories have successfully guided clinical treatments for thousands of years. The academic succession of TCM theories has continued for a long time, but the Chinese medical dosage theories were a secret. The Chinese medical dosage theories are an important part of TCM theory, and special dosage is the key to better effect. Appropriate dosage is an important factor to ensure safety.Shanghan Zabing Lun (Treatise on Cold Pathogenic and Other Diseases) written by Zhang Zhong-jing with strict formulation and precise prescription was looked upon as the progenitor of prescription books and was called "classical prescriptions". So the question is what the original dosage of classical prescription is. The conclusion is "one Liang in Donghan dynasty approximated 13.8g"The dosage range of many herb drugs in national pharmacopoeia and Chinese Pharmacy textbooks have many differences with nowadays. Therefore, the main objective of this dissertation is to find the dosage range of the commonly used Chinese drugs in classical, prescription in The Wei Jin Southern and Northern dynasties and The Sui and Tang dynasties, to summarize the characteristics and features and control strategies of Chinese medication usage in clinical practice by doctors in Tang dynasty, and to find how the decocting power be used by the doctors in that period.1 Objective(1) Choosing fifty commonly used Chinese drugs in Shanghan Zabing Lun, studying the clinical dosage rules and features of doctors'using Chinese medicine in Tang dynasty.(2) Calculating the dosage range of 50 commonly used Chinese drugs in Shanghan Zabing Lun according to the conclusion that one Liang in Donghan dynasty approximated 13.8 g, and finding the differences of dosage from Donghan dynasty to Tang dynasty.(3) Calculating the common dosage range of 50 frequently used Chinese drugs, in comparison to the dosage ranges in national pharmacopoeia. Summarizing the differences of the doctors'using Chinese drugs between Tang dynasty and contemporary time.(4) Calculating the total dosage, in comparison to the dosage in national pharmacopoeia and Shanghan Zabing Lun. Summarizing the differences between the doctors'using the total dosage in Tang dynasty and in contemporary time, in order to prove the conclusion that one Liang in Donghan dynasty approximated 13.8 g.(5) Calculating the number of the decocting power in Waitai Miyao, in comparison to the dosage in Song dynasty. Summarizing the influence of the changes to unveil the decline of original dosage of classical prescription. 2 ContentsThe fifty frequently used Chinese drugs chosen by studying team were the research objects, while the research contents were Waitai Miyao published in Tang dynasty. The dosage features of the fifty Chinese drugs will be studied, including the average dosages, the common dosage range, the most frequently used dosage, and the distribution extent from the minimum to the maximal dosage.The books was listed as follows:The Dong Han dynasties:Shanghan Zabing Lun; The Wei Jin dynasties:Zhou Hou, Fan Wang Fang; The Southern and Northern dynasties:Xiao Pin Fang, Shen Shi Fang, Ji Yan, Shan Fan, Tao Shi Fang; The Sui and Tang dynasties:Gu Jin Lu Yan, Qian Jin Yao Fang, Qian Jin Yi Fang, Guang Ji, Yan Nian, Jiu Ji, Cui Shi Cuan Yao Fang, Zhang Wen Zhong Fang, Xu Ren Ze Fang, Bi Xiao, Jin Xiao.3 MethodThrough the Excel table processing function and basic statistical methods, obtain the occurrence frequency, the common dosage range, the average dosage, the most frequently used dosage, and the distribution extent from the minimum to the maximal dosage of the fifty Chinese drugs.4 ResultsThe results of the study will be separated into two parts, one is the general discussion about the fifty herb drugs, the other is individual exposition. The main results are stated as follows:(1)The common dosage range, the average dosage, the most frequently used dosage, and the distribution extent from the minimum to the maximal dosage of the fifty Chinese drugs in Waitai Miyao and in Shanghan Zabing Lun are the same. The dosage range of the fifty commonly used Chinese drugs in Waitai Miyao is close to the dosage range of these drugs in Shanghan Zabing Lun.(2) The common dosage range, the average dosage, the most frequently used dosage, and the distribution extent from the minimum to the maximal dosage of the fifty Chinese drugs in Waitai Miyao were all higher than those in contemporary time. The dosage of common Chinese drugs in contemporary time is mainly distributed in from one tenth to one third of the dosage of common Chinese drugs in Waitai Miyao.Taking the most frequently used dosage for example, the dosage of most drugs in Tang dynasty was higher than the dosage listed in national pharmacopoeia.(3) The formulas which calculated total dosage were 445 in Waitai Miyao. The common dosage range was described by the range of [P25~P75]. The range of total dosage was 131g~331g:the range of the numbers was 4-8; the range of the water was 1200-1800ml; the ratio of the total dosage and the numbers was 27.6-48.3; the ratio of the water and the total dosage was 5~9 ml/g.(4) The calculated formula of the decocting power was 25 in Waitai Miyao. The dosages of the decocting power each time were 4.3 g and 45.79 g. In comparison to the decoction dosage in Tang dynasty, the dosages of decocting power were less than the dosages in decoction.5 Analysis & DiscussionThe conclusion can be obtained that the original dosage of classical prescription did not decline from Donghan dynasty to Tang dynasty. Therefore, the emphasis in this part is to search the original dosage of classical prescription and unveil the decline of original dosage of classical prescription.(1) The dosage of common Chinese drugs did not change much from Donghan dynasty to Tang dynasty. It means that the dosage of Tang dynasty carry on the characteristics of the original dosage of classical prescription. There was simultaneous existence of simple and complex prescriptions.The dosages of special prescription were more than the dosages in Shanghan Zabing Lun. It illustrates that the dosage of classical prescription did not belong to the surpass dosages in Tang dynasty. That can support the conclusion "one Liang in Donghan dynasty approximated 13.8g".(2) Comparing the common dosage range of 50 frequently used Chinese drugs in national pharmacopoeia and Waitai Miyao, the dosage range in Waitai Miyao was wider than those in national pharmacopoeia. That can illustrate the dosages were changeful in Tang dynasty. On the contrary, the common dosage ranges in national pharmacopoeia were conservative.(3) The characteristics of the total dosage and the number in Waitai Miyao followed the rules of Shanghan Zabing Lun. Most of the proportion of water and the total dosage were appropriate. That can support the conclusion "one Liang in Donghan dynasty approximated 13.8g".(4) The decocting power had already developed in Tang dynasty, and it was not first invented in Song dynasty.But the decocting power prevailed in Song dynasty, and took the place of decoction. The dosage of decocting power was small, and the formular was complex, and one dose was taken for many times. The characteristics of decocting power were quite different from those in Tang dynasty. Therefore, the changes from the decoction to the decocting power had big influence in the important period. |