Research On Two-Dimensionality Hierarchical Model And Method For Pharmaceutical Product Family Design

Pharmaceutical manufacturer should resonably determine product categories, quantity and combination mode for effective utilization of enterprise resources, seizing the opportunity, avoiding risks and threats. Pharmaceutical manufacturer systemly think effective structure of width, depth, length, and correlation of product line based on operation target. So this paper studies the development and design of the medical products on the basis of the design methods of product family. It is significant for our country to promote the independent innovation, increase the ability of research and development,improvement and innovation,variety of dosage forms,and reinforce the international competition. This undoubtedly,not been reported,has important academic value and practical significance.The main work and innovation points of this paper are following:Firstly, this paper proposes pharmaceutical product families based on the mass customization. On the basic categorization and characteristics of pharmaceutical product families,which pharmaceutical product families are mainly classified as four categorization, general design methods were given for pharmaceutical product families. Two-dimensionality hierarchical model was proposed for design of pharmaceutical product families based on the concept model frame of a two-dimension analytical model.Secondly, this paper research requirement and target of the composing dimension model about pharmaceutical product families by analyzing physical composition of drug and comparing with machine product families. It was discussed about expression, hierarchical model, method and thinking of the composing dimension, including Schematic diagram.Thirdly, the developed process hierarchical model is proposed for pharmaceutical product families. And it was discussed mapping relation between patient requirement spaces, treating principle spaces, treating function spaces and physical composition spaces of drug. The whole frame of two-dimension hierarchical model of pharmaceutical product families is built based on the developed process and the composing dimension hierarchical model.Fourthly, based on two-dimensionality hierarchical model of pharmaceutical product families, the process of two-dimensionality hierarchical design is proposed. It includes making product families strategies for pharmaceutical industry, constructing two-dimensionality hierarchical model, generating platform-based drug variants and customization drug being configured. The paper discussed how two-dimensionality hierarchical of pharmaceutical product families evolves.Fifthly, by comparing pharmaceutical product family and machinery manufacturing product family's mathematical optimization model, the most important work is process simulation for optimization design of pharmaceutical product family. This article gives general model to correlate the solubility of pharmaceutical compounds with the variation of both temperature and initial composition of binary solvent mixtures for optimization design of pharmaceutical product family.Sixthly, two-dimensionality hierarchical model and method for pharmaceutical product family, studied in this paper, are applied in two examples.