| With advances in medicine and change of medicine model,it is interested by more and more people about the theory of constitute of TCM, and actively carried out a lot of correlated research. Chronic primary glomerular disease is a kind of prevalent kidney disease, and is the main cause of the end stage renal disease (ESRD).,which resulting in the decline of quality of life and age, bringing huge economic burden to the family and the society. So it is very important to.early discovery and treatment. However kidney disease onset conceals, it is hard to differentiate symptoms and signs in initial stage.The theory of constitute of TCM has a great advantage in the prevention of disease and early treatment of chronic kidney disease, and can be applied to research and treatment of primary kidney disease.Objective: By observing the constitution, the people general state of health, sydrome and symptoms, clinical indicators of chronic primary glomerular disease by sampling survey with random, we try to analyze the correlation between these by mordern statistics, to explore the clinical characteristics between different type of constitution in chronic idiopathic glomerular disease for, TCM individualized prevent and treat chronic primary glomerular disease.By this way,we try to find a new way to prevent and cure chronic primary glomerular disease.Methods:by observing the general state of health, sydrome and symptoms, clinical indicators of the people meeting the inclusion standards, filling in questionnaire of constitution,applying modern statistical methods, explore the different physical characteristics in different constitution in the disease. And through observe the level of TGF-βin the serum and urine of primary glomerular diseases, combined with the constitution and kidney pathological, analyzing the correlation between it, we try to find a new way to prevent and cure chronic primary glomerular disease.Results:1. Deficiency Qi of constitution, Deficiency Yang of constitution, and normal constitution is more common in Chronic primary glomerular disease. At the same time different constitutions have distribution of syndrome. Deficency of lung qi and kidney qi syndrom can be seen as usually from deficency of qi constitution(47.5%).The second syndrom can be seen in this constitution is deficency of spleen yang and kidney yang syndrom.In deficency of yang constitution the most syndrome is deficency of spleen yang and kidney yang syndrom (40.54%), and secondly is deficency of lung qi and kidney qi syndrom. Yang, the virtual qualitative patients with spleen and kidney Yang syndrome (most 40.54% issuing), lung kidney deficiency syndrome.The most syndrome in constitution is deficency of lung qi and kidney qi syndrom. There were statistically significant with difference between deficiency of qi and yang constitutions and not these constitutions. The syndrome of excess were no differences,and the most frequent is syndrome of dampness and heat and syndrome of dampness.2.According to results of proteinuria, deficiency of qi and yang constitutions with gallery level of proteinuria has conspicuous correlation. And urea nitrogen, creatinine and triglyceride in serum has conspicuous difference between various constitutions(p<0.05). In creatinine level the highest is difficiency of yang constitution, the least is normal constitution. And there are conspicuous difference between difficiency of yang constitution and deficiency of qi constitution, normal constitution (p<0.05). Deficiency of qi constitution is the highest in the level of plasma-albumin.and exist conspicuous differences with the other constitutions(p<0.05). Other constitutions group has the highest level of triglyceride and cholesterol, and exist conspicuous differences. There are different level of complement C3 between various constitutions (p<0.05).And the highest is difficiency of yang constitution,the minimun is normal constitution and stagnation of qi constitution in level of complement C3.Meanwhile, normal constitution with difficiency of yang constitution, difficiency of qi constitution has apparent difference(p<0.05), stagnation of qi constitution with difficiency of qi constitution has apparent difference(p<0.01).3. Mesangial proliferative glomerulonephritis(37.5%) and membranous nephropathy (37.5%) is the most in normal constitution.In difficiency of qi constitution, the most is also mesangial proliferative glomerulonephritis(42.1%).And in difficiency of yang constitution, the most is sclerosing glomerulonephritis (40.6%).Compare with normal constitution and difficiency of yang,the difference is remarkable in distribution of type of pathology(p<0.05)4.TGF-beta level in patients of chronic primary glomerular disease is 163.99±67.42,which is higher than healthy people(p<0.01).The level of TGF-beta in serum is the highest in sclerosing glomerulonephritis, the second in minimal change nephropathy. And these two types of pathology is predominance difference compared with MPG and MN(p<0.05).From aspect of constitute of TCM, The level of TGF-beta in serum is difference in various constitution(p<0.05),which has statistical significance.And difficiency of qi constitution has the highest level of TGF-beta in serum.normal constitution and difficiency of yang,the difference is the minimum.Meanwhile these distribution has significance in statistic(p<0.05).5. The level of TGF-beta in serum relates to IgA. IgM. The level of TGF-beta in urine relates to lgA. lgG,and is negative correlation to complement C3.According to gradual regressive analysis, regression equation of the level of TGF-beta in serum and IgM is y=713.526+344.86x, the regression equation of The level of TGF-beta in urine and IgG is y=64.423+12.12x.Conclusions:(1) There are differences in various constitutions. And different constitution has respectively characters in the aspects of syndrome, symtoms, clinical index, type of pathology,and so on. Pathogenetic condition is heavier in the difficiency of yang constitution. (2)TGF-beta level in patients of chronic primary glomerular disease can increase,and exist different correlation about type of pathology and constitution.At same time, the raising of TGF-beta may be relate to immunologic mechanism,except procedure of fibration. (3)The relationship with difficiency of qi constitution and this disease, may be reflect to aspect of immune by TGF-beta.
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