The Relation Between Peripheral Blood ACE, SP And Pathogensis Of Sarcoidosis

Sarcoidosis is a multisystem granulomatous disease of unknown etiology with the presence of noncaseating. The lungs and hilar lymph nodes are often involved. The interstitial fibrosis caused by the disease in the last stage results in respiratory failture frequently. Though the steroid can inhibit the activity of sarcoidosis, the fibrosing process could not be affected Since the pathogenesis of sarcoidosis is until not clear, the diagnosis and treatment of the disease are not satisfactory.SACE has been widely used as a marker for diagnosis and determining the activity of sarcoidosis, since Liberman noted that sarcoidosis patients have a markedly elevated serum ACE concentrations in 1975. Some people suppose one mechanism to explain the reason which is not clear now, that is the effect of ACE on inflammation may be due either to the inactivation of bradykinin(BK), or to the metabolism of neuropeptides such as substance P. It is belived that the epitheliod cells, alveolar macrophages which are derived from monocytes in granulomata are the source of the elevated serum enzyme in the cases, and lymphocytes only have an indirectly effect on modulating...