Relationship Between Plasma Matrix Metalloproteinase-9 And Hemorrhagic Transformation In Actue Ischemic Sroke

Part ISystematic review of relationship betweenplasma matrix metalloproteinase-9 and hemorrhagic transformation in ischemic strokeObjectives: To study the relationship between matrix metalloproteinase-9 (MMP-9) and hemorrhagic transformation (HT) in ischemic stroke and provide evidences for the further clinical studies, selection of patients for thrombolytic therapy, and application of MMP inhibitors to clinical practice to extend the windows for thrombolytic therapy.Methods: The studies on relationship between MMP-9 and HT in ischemic stroke were included, in which HT was followed up based on plasma level of MMP-9 or comparison of plasma level of MMP-9 was conducted based on whether HT or not, regardless of langue of publication and type of studies. MEDLINE (1966-APRIL 2006), EMBase (1966-APRIL 2006), CNKI (1977-FEB 2006), and wanfangshuju (1989-2005) were searched and the references lists of eligible studies were manually searched. Two reviewers independently evaluated the quality of studies and extracted data. The data were analyzed using the Revman 4.2. and SPSS 11.0.Main results: 6 trials fulfilled the inclusion criteria, including 558 patients, 130 of them developed hemorrhagic transformation. The heterogeneity...