| Objective: High levels of serum magnesium can reduce the risk of cerebral infarction and post-infarction hemorrhagic transformation(HT)by improving vascular endothelial function,improving arteriosclerosis and reducing oxidative stress.High levels of matrix metalloproteinases-9(MMP-9)are closely related to infarct extension,neurologic deficits,and HT in patients with acute ischemia.It has been found that serum magnesium in low level increase MMP-9 content and activity.This study is to detect the contents of serum magnesium and MMP-9 in patients with acute ischemic stroke,and to discuss their relationship with the hemorrhage transformation of acute ischemic stroke and clarify possible mechanisms.Methods:301 patients with acute cerebral infarction received therapy of Neurology in the First Affiliated Hospital of Wannan Medical College from September 2018 to September 2019 were included in the study.Among them,28 patients had hemorrhagic transformation after ischemic stroke,and 273 patients had non-hemorrhagic transformation.After all patients were included in the study,detailed clinical data of the patients were collected,and 4-5 ml of their venous blood was collected in the early morning of the next day.The serum MMP-9 content was detected through enzyme-linked immunosorbent assay(ELISA).Diagnosis and treatment were performed according to the clinical path of cerebral infarction of the Ministry of Health.This study did not impose any intervention measures on the treatment of patients.The relationship between serum magnesium,MMP-9 and HT was examined by applying statistical software.Results:1.The serum magnesium level in hemorrhagic transformation group was0.79±0.15mmol/L,and the non-hemorrhagic transformation group was0.87±0.20mmol/L.The serum magnesium level in hemorrhagic transformation group was conspicuous less than control group(P<0.05);The serum MMP-9 content in the hemorrhagic transformation group was 186.54±55.70ng/m L,and the serum MMP-9content in the control group was 164.63±51.11ng/m L.The serum MMP-9 content in hemorrhagic transformation group conspicuous exceed control group(P<0.05).2.No conspicuous discrepancy were found in serum magnesium levels in patients with different subtypes of acute cerebral infarction,different MMS model score subgroups and different degrees of neurological deficits(P>0.05).There were differences in the distribution of serum magnesium between different THRIVE model score subgroups.The serum magnesium levels of the 5 and above groups were significantly lower than those of the 0-2 and 3-4 groups(P<0.05).No conspicuous discrepancy were found in serum MMP-9 levels in patients with different subtypes of acute cerebral infarction,different MMS and THRIVE model score subgroups and different degrees of neurological deficits(P>0.05).3.Serum magnesium levels in patients with acute ischemic stroke were not associated with MMP-9 content(P>0.05).Serum magnesium level was positively correlated with platelet content and creatinine concentration at admission(P<0.05),and negatively correlated with MSS score grade(P<0.05);serum MMP-9 level was positively correlated with creatinine concentration(P<0.05).4.Univariate analysis of cerebral infarction hemorrhage transformation showed that risk factors for hemorrhagic transformation were history of atrial fibrillation and hypertension,NIHSS score,platelets,serum magnesium,high density lipoprotein.Through multivariate logistic regression analysis,the independent risk factors for hemorrhagic transformation were a history of atrial fibrillation and severe neurological deficit.Conclusion:1.Serum magnesium and MMP-9 were likely to used as a measure to evaluate the venture of HT in patients with acute ischemic stroke.2.In patients with acute ischemic stroke,serum magnesium levels were not associated with MMP-9 levels at admission.3.Independent risk factors for hemorrhagic transformation were a history of AF and Severe neurological deficit(NIHSS score ?15 on admission). |
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