1. Association Of Bone Mineral Density With Polymorphism Of Leptin Receptor Gln223Arg Gene And Peroxisome Proliferators-activated Receptor Gamma C161â†'T Gene In Women Of The Han Nationality In Beijing Area 2. Effects Of Parathyroid Hormone Fragment-(1-34

[Background and Objective]The important predictors of osteoporosis and fracture are peak bone mass and bone mass loss, which are predominantly determined by genetic factors, therefore it is required to clarify these genetic risk factors for osteoporosis. If the relevant genes were identified, the peoples who are more susceptible to osteoporosis will be early screened and prevented as soon as possible, which can reduce the prevalence of osteoporosis and fracture. Presently there have been many investigations about association of bone mineral density(BMD) with genes as genetic risk factors. Concerning the polygenic nature of BMD and many endocrinological factors known to regulate bone mass and bone turnover, it is very important that the panel of candidate genes should be expanded to elucidate the whole mechanism of the genetic aspect of osteoporosis.Leptin has emerged as a key element in the regulation of bone mass.The biological actions of leptin on target tissues are carried out through binding to its specific receptor. The expressions of leptin receptors(LEPR) mRNA and protein in osteoblast, chondrocyte and osteoclastic progenitor were demonstrated. There existed a Gln223Arg polymorphism in exon 6 of LEPR gene.The LEPR Gln223Arg polymorphism is within the region encoding the extracellular domain...