Association Of Parathyroid Hormone Gene Polymorphism With Bone Mineral Density And The Effects Of Human Parathyroid Hormone Fragment (1-34) On Human Osteoblast-like SaoS-2 Cells

Part 1Association of parathyroid hormone gene polymorphism with bone mineral density of Han nationality women in Beijing areaObjectives Osteoporosis was a skeletal disease characterized by low bone mineraldensity (BMD), bone microarchitectural destruction leading to enhanced bone fragility, and a consequently increase of fracture risk. Osteoporosis belonged to the most common disorders of aging which was a genetic disease associated with many genes. The peak bone mass, bone mineral density, bone mass loss rate were under strong genetic control. Many research focused on exploring the relationship between gene polymorphism and BMD. The association of Vitamin D receptor gene polymorphism and BMD was reported firstly, then the relationship between BMD and gene polymorphism of calcitonin receptor, estrogen receptor, type I collagen, transforming growth factor and so on were reported, however, the results were not concordant completely in different population.As we know, parathyroid hormone (PTH) was one of the most important hormones which modulated bone turnover, calcium and phosphate metabolism. The number, function and apoptosis of osteoblast and osteoclast were also significantly...