Kidney And Bone Tonic Decoction Effect On Parathyroid Hormone And Bone Density Of Patients With Renal Bone Disease

Objective: To study the effect of tonifying kidney and strengthening bone mixture on parathyroid hormone and bone mineral density in patients with renal osteodystrophy.Methods: 1.The clinical observation of 60 cases of liver kidney yin deficiency syndrome CKD3-4 stage renal osteodystrophy.A total of 60 cases Patients were randomly divided into treatment group and control group,30 cases in each group,Give a low salt,low fat,low dietary phosphorus,calcium(daily to Calcium Carbonate Tablets 600 mg,ossification in three alcohol 0.25 ug,On the 1 day,oral),control blood pressure,lipid,creatinine,anemia,anti infection,correct acid-base and electrical Solution quality disorder and other symptomatic support treatment,the treatment group on the basis of the control group was treated with Bushen bone mixture.Two The course of treatment was 3 months.The age,sex,course of disease,body weight,height,primary hair of two groups before treatment.There was no significant difference in the distribution.2.To observe the bone mineral density of lumbar spine in two groups of patients before and after treatment(BDM),parathyroid hormone(PTH),electrolytes(Ca,P),calcium and phosphorus product(Ca * P),alkaline phosphatase(ALP),renal function(Scr,BUN,GFR)changes of red blood cell count and hemoglobin,and note the changes record two groups of patients with associated symptoms and signs,to analyze the statistical data by SPSS18.0 software,compared to the treatment effect,determine the difference between the two groups of patients after treatment in the curative effect.3.To observe the changes of main symptoms before and after treatment of two groups,and quantify the symptom integral,then analyze the effect.Results:1.The two groups in the total clinical efficacy of comparison: the total efficiency of treatment group was 86.67%,control group total effective rate was53.33%,there was significant difference between two groups(P=0.039<0.05).The treatment group was better than the control group after treatment.2.In two groups of TCM syndrome curative effect comparison: the efficiency of treatment groupwas 90%,the control group was 53.33%,the difference was statistically significant(P=0.001<0.01).The improvement of TCM symptoms in the treatment group was better than that in the control group after treatment.3.The change in calcium,phosphorus,alkaline phosphatase: before and after treatment,compared two groups in calcium,phosphorus,alkaline phosphatase had significant difference in the improvement of cellular immunity(P<0.05),the treatment group are obviously better than the control group.4.Comparison of two groups of patients with parathyroid hormone,lumbar bone mineral density index: the two groups after treatment were statistically significant(P<0.01).Comparison between groups,the treatment group is better than the control group,after treatment,the treatment group was better than the control group in reducing the level of parathyroid hormone and increasing the bone mineral density.5.Comparison of two groups of patients with serum calcium,phosphorus and calcium phosphorus product,alkaline phosphatase index: there were significant differences between the two groups after treatment(P <0.05 or <0.01).Comparison between groups,the treatment group is better than the control group,after treatment,the treatment group in serum calcium,serum phosphorus,calcium and phosphorus product alkaline phosphatase related index is better than the control group in those.6.Two groups of patients with renal function(Scr,BUN,GFR)and other indicators of comparison: compare the indexes of renal function after treatment in the treatment group,the difference was statistically significant(P<0.05 or <0.01),the control group had no significant difference(P >0.05),comparison between groups,the treatment group is better than the control group.The treatment group can improve renal function.7.Comparison of two groups of patients with red blood cell count and hemoglobin,after statistical treatment,the treatment group had significant difference(P <0.05 or <0.01),was statistically significant difference between the control group(P<0.01),comparison between groups,the treatment group is better than the control group,the treatment group in improving red blood cell count and hemoglobin is better than the control group in those.Conclusion:1.The efficacy of the combined application of tonifying kidney and bone strengthening mixture in the treatment of liver kidney yin deficiency syndrome of CKD3-4 stage renal disease was better than that of the control group.2.The combined application of tonifying kidney and strengthening bone mixture can improve the symptoms of patients with liver kidney yin deficiency syndrome in CKD3-4 stage,and the curative effect is better than that of the control group.3.The combined application of tonifying kidney and bone strengthening mixture in the treatment of liver and kidney yin deficiency CKD3-4 renal osteodystrophy can improve the disorders of calcium and phosphorus metabolism(increased blood calcium,blood phosphorus,reduce),reduce the parathyroid hormone level of patients,and increase the bone mineral density of lumbar spine,the treatment effect is better than single therapy.4.The combined application of tonifying kidney and bone strengthening mixture in the treatment of liver and kidney yin deficiency CKD3-4 renal osteodystrophy can improve the metabolism of calcium and phosphorus metabolism and abnormal bone metabolism,improve renal function,anemia and delay the progression of CKD disease,the treatment effect is better than single therapy,it is worthy of further promotion.5.During the treatment,two groups of patients were not found any toxic side effects and serious adverse clinical reactions,namely "Tonifying kidney and bone strengthening mixture" is a traditional Chinese medicine mixture and safe for the treatment of patients with renal osteodystrophy liver kidney yin deficiency syndrome CKD3-4 useful.