Mechanism Research On The Action And Influence To Hyperthyroidism Model Of Decoction-Chaixia

Objectivehyperthyroidism graves refers to a group of endocrine diseases due to hyper thyroid function and increased thyroxin in the blood. Its symptoms and signs include sweating, nervousness, fatigue, insomnia, sensitivity to heat, less of weight and bulging of the eyes etc. In order to curative the mechanism and curative effect of decoction-CX, we have used new theories and methods of modern medicine to make experimental study of hyperthyroidism. MethodsThe model was reconstructed: The Wistar rats were mainlined Tablet-JZX 5mg/100g per day fourteen days. The blood and thyroid gland were drawed in fourteenth day. The FT3, FT4 were measured.The curative mechanism experiment we divided the Wistar rats into Normal group, Model group, Traditional Chinese medicinal group, The high dose group of decoction-CX, The normal dose group of decoction-CX, The low dose group of decoction-CX. These rats were cured fourteen days. Their bleed and thyroid glands were drawed. The FT3, FT4 were measured by RIA, the thyroid c-fos, TGF- β 1 were observed in situ hybridization and the histological changes were observed by light microscooes. Resultsin the model group, serum levels of FT3, FT4 was higher than Normal group(P<0.001). The results of common pathology study showed that the majority of thyroid follicle epithelial cells appeared with cube shape and the minority low pole. The capillaryamong interstitial tissue dilated. There was sorb vacuole in some follicle.The study of symptom and signs showed that the rats of model group acted more frequently, drunk more water, and were mental disturbance in the nonage, and become thin, acted for shorter time and stool was watery after the model was formed. Their weight was lower than Normal group(P<0.001). The symptom and signs in the curative groups oberviously improved, the most significant was The high dose group of decoction-CX.The RIA measure results showed the serum levels of FT3, FT4 , TSH, TG, γ -T3 in the model group obviously rectified in most curative groups.the results in situ hybridization showed that the expression of c-fos were high, and TGF- β1 was low. The results were changed by the curative groups, the most significant among them was The high dose group of decoction-CX.The study of common pathology showed that the follicles are small and lined with hyperplastic columnar epithelium and contain scant colloid that displays much marginal scalloping and vacuolization . The nuclei are vesicular and basally located and exhibit occasional mitoses , papillary projections of the hyperplastic epithelium extend into the lumina of the follicle. Vascularity is increased, and there is a varying infiltration by lymphocytes and plasma cells.The instance above improved in all curative groups, and the most effect among them was the high dose group of decoction-CX. Conclusion...