Theoretical And Experiment Study On Tong-Er-Shou Tablet In Treating Adiposis And Constipation

The present study was performed under the instruction of my tutor and based on the summary of the previous understandings and the recent achievement on adiposis and constipation. The purpose of my study was to investigate the reasons and mechanisms that adiposis and constipation become so popular today by analysising the epidemic features of the two diseases, further to find whether there is some relationship between them. So we could find some new therapeutic principle and method. At the same time , we performed an advanced pharmacodynamics research of Tong-Er-Shou Tablet, an clinically-proved effective medcine treating adiposis and constipation .Our results show that alimentary obesity rat model can be induced by high fat and high carbohydrate feeding. The features of the rat models coincide with that of human being and can be used for the pharmacodynamics research of Tong-Er-Shou Tablet. Further reserch shows using Tong-Er-Shou Tablet can lower rat weight, reduce abdominal fat content, decrease the serum levels of triglycerides , totel cholesterol and LDL-C and increase the serum levels of HDL-C . At the same time the levels of leptin, tumor necrosis factor, MDA and the activity of FAI-ldecreased, while the activity of SOD increased. Also, by lowering blood viscosity, serum glucose and insulin level, using Tong-Er-Shou Tablet can ameliorate insulin resistance. We also investigate the effect of Tong' ersou on NO synthetase, the result shows using Tong-Er-Shou Tablet can down-regulate the gene expression of iNOS in white blood cells and up-regulate the serum level of eNOS. Using Tong-Er-Shou Tabletcan increase defecation of both normal and constipated rats by facilitating intestinal motility , softening feces and can antagonize the inhibition of intestinal motility induced by adrenamine, atropine and morphia.Improper diet and inadequate physical activity are the main causes of adiposis of modern society. While stress plays a key role in the onset of constipation. By introducing the concept of nervous-endocrine-immune net into the reserch of adiposis and constipation, and investigating them at two aspect: western medicine and traditional Chinese medicine, we concluded there are some identity between the two disease. We also proved Tong-Er-Shou Tablet is reliable in pharmacodynamics and is an effective medicine treating adiposis and constipation.