| ObjectiveThe aims of this research were: 1) to summarize the pathological mechanism and therapeutic methods of chronic pelvic inflammatory disease (CPID); 2) to analyze the essential pathogenic & pathological mechanism of CPID from the point of view of traditional Chinese medicine (TCM); 3) to investigate the curative effects of Tonifying the Kidney & Soothing the Liver (TK&SL) on CPID; 4) to explore the therapeutic mechanism of TK&SL.MethodsClinical evaluations are made on 60 patients suffering from CPID. They are randomly divided into two groups in the proportion of 2 to 1. Forty patients are treated by TK&SL granule compared with 20 patients who are treated by Fu Ke Qian Jin troche (FKQJ). All patients are evaluated at physical sign integrals, syndrome integrals and integrated integrals, examined by pelvic ultrasonic inspection before and after 2 months' treatment. And 20 patients are randomly sampled from TK&SL group to detect the concentration of ?, PRL, TNF-α and SOD in serum, the concentration of TXEB2 and 6-Keto-PGFlα in plasma, the concentration of TNF-a and slgA in cervical mucus.Results1) Integrated therapeutic effects: 16 cases are completely cured (40%), 21 cases showing apparent effects (52.5%), 3 cases showing visible effects (7.5%), none being of no effects in the TK&SL group, while 4 cases are completely cured (20%), 10 cases showing apparent effects (50%), 5 cases showing visible effects (25%), 1 case being of no effects (5%) in the FKQJ group. Physical sign effects: 15 cases are completely cured (37.5%), 18 cases showing apparent effects (45%), 7 cases showing visible effects (17.5%), none being of no effects in the TK&SL group, while 4 cases are completely cured (20%), 7 cases showing apparent effects (35%), 8 cases showing visible effects (40%), 1 case being of no effects (5%) in the FKQJ group. Syndrome effects: 17 cases are completely cured (42.5%), 22 cases showingapparent effects (55%), 1 case showing visible effects (2.5%), none being of no effects in the TK&SL group, while 4 cases are completely cured (20%), 11 cases showing apparent effects (55%), 4 cases showing visible effects (20%), 1 case being of no effects (5%) in the FKQJ group. There are significant statistical differences in the therapeutic effects of both group.2) The physical sign integrals, the syndrome integrals and the integrated integrals are remarkedly improved in both groups. The improvement is more apparent in the TK&SL group than in the FKQJ group.3) Many symptoms are alleviated better in the TK&SL group than in the FKQJ group, such as lumbago, tenesmus, distension and pain of the breasts and flanks, hypodynamia, fatigue, being vexed, depression, irregular menses, abnormal pulse condition, low fever, dizziness, frequent or urgent micturition, diarrhea or constipation, abnomal tongue condition. Some physical signs are alleviated better in the TK&SL group, such as tenderness of the uterus, swelling of one side of adnexa, swelling or tenderness of the sacrum ligament and uterine immobility. Ultrasonic examination results of uteritis are improved better in the TK&SL group.4) There are no significant statistical differences among the patients with different ages and courses of disease in the TK&SL group, while the integrated therapeutic effects on patients suffering from mild CPID are much better than patients suffering from moderate and severe CPID.5) The plasma concentration of 1X82 and the ratio of TXB2 to 6-Keto-PGFla are reduced after treatment with TK&SL.6) The concentrations of TNF-a and slgA in cervical mucus are elevated after the treatment of TK&SL, while the concentration of TNF-a in serum is reduced after treatment with TK&SL.7) The concentration of PRL in serum is reduced after treatment with TK&SL, while there is no signigicant statistical difference in the concentration of ? in serum before and after the treatment.8) The concentration of SOD in serum is remarkedly reduced after treatment with TK&SL.9) No other side effects are found in both groups ex...
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