Study The Anesthesia Effect And The Security Of Capsaicin

Objective Determine ideal doses of CAP which can increase pain threshold while no microstructure of spinal and nerve roots changes when it was injected into epidural space of rats. Study the security and anaesthesia effect.Methods ninety - six adult Wistar male rats 250 ~ 300 g were randomly divided into four group A, B, C, D. A catheter was inserted into epidural space at L5 as Yaksh methods. 1 mg/ml (group A) ,2.5 mg/ml (group B) ,5 mg/ml (group C) CAP 0.4 ml were inject into epidural space Control group (group D) were inject 10% Tween 80. Observe the changes of microstructure of spinal and nerve root under microscope and electron microscope. The pain threshold were examined before and after CAP was injected 3,7,14 days.Results Microscope and electron microscope indicated: 1 mg/ml CAP increases pain threshold of rats while no microstructure changes. 2.5 mg/ml-CAP increases pain threshold of rats while microstructure changes slightly. 5mg/ml CAP increases pain threshold of rats remarkable meanwhile cause microstructure irreversible damage.Conclusions CAP It can be used as an ideal long potential anaesthesia agent.