Clinical Effect And Mechanism Of Electroacupuncture And Acupoint Injection On Lumbar Intervertebral Disc Protrusion

Objective:Clinical cases with lumbar intervertebral disc protrusion clinical observation, study the curative effect of acupuncture and acupoint injection in the treatment of intervertebral disc herniation; By animal experiment research of acupuncture and acupoint injection on the animal model of lumbar New Zealand white rabbit lumbar intervertebral disc protrusion between disc tissue BCL-2, Bax, Casp3 gene mRNA expression, the influence of explore the possible mechanism of the treatment of lumbar intervertebral disc protrusion.Methods:The clinical part including 94 cases of patients with lumbar disc prolapse were randomly divided into treatment group, the acupuncture point injection group were treated with electric acupuncture and acupoint injection, the cases of 80 cases of complete collection. One (1) electric acupuncture treatment group 40 cases. (2) acupoint injection group 40 cases.Clinical sections:90 cases of patients with lumbar disc prolapse were randomly divided into two groups, the electric acupuncture treatment group and acupoint injection group. They are treated with electric acupuncture and acupoint injection respectively. Between the treatment process,7 cases were fallen off,7 cases were excluded, finally finally completed to collect 80 cases, including electric acupuncture treatment group is 40 cases,40 cases in point injection group.Interventions:(1) electric acupuncture treatment groupMain point:gv 3 o, rubs, rank, is acupuncture point; Match point:shenshu, bilateral, gb 34, Queensland. Main point for each choice, the rest of the acupuncture points with the add and subtract. Qi, with acupoint nerve stimulator, continuous treatment 6 days for a period of treatment, treatment 3 period of treatment, the treatment interval of 1 day.(2) acupoint injection groupMain point:the waist is point o, shen shu, liver shu, bilateral (more than is acupuncture point acupuncture point injection, filiform needle acupuncture)Match point:cold dampness lumbago and gv 3; The lumbago with blood, blood for shu; Add too creek, liver and kidney deficiency; Du meridian back pain and waist clip ridge, si 3; Bladder lumbago and chamber, Queensland warehouse; Lumbar di ministry pain and skeleton, yao shu; More than with the add and subtract.Depth of subcutaneous injection of 1.5 cm, injectable drugs for triamcinolone acetonide 40 mg, vitamin B120.5mg,1 ml of 2% lidocaine. Each meridian 1.5 ml.Experimental part:3.0-4.5 kg 24 rabbits were randomly divided into four groups (normal group, model group, EA group, acupoint injection group), each group is 6 rabbits. In addition to the normal group, set up after lumbar disc degeneration model and to the relevant processing, measuring lumbar disc tissue Bcl-2, Bax, Casp3 gene mRNA expression.Results:(1) Electric acupuncture and acupoint injection can reduce VAS score, TCM syndrome in patients with lumbar disc prolapse SI scores, JOA score and the curative effect is better than acupuncture point injection. (2) Acupuncture and acupoint injection of LDH white rabbit stimulates the BCL-2 gene mRNA expression, the expression of Bax gene, gene mRNA Casp3 has inhibitory effect.Conclusion:(1) Both the electric acupuncture and acupoint injection can effectively relieve the clinical symptoms in patients with lumbar disc prolapse, and cupping treatment group is better than the acupoint injection group.(2)Two treatment groups all can promote the LDH white rabbit the BCL-2 gene mRNA expression of Bax gene, Casp3 inhibition gene mRNA expression, also in this way, we can reduce the sensitivity of cell apoptosis, enhance the capacity of antiapoptotic, thus regulating the lumbar disc degeneration.Apoptosis resistance capability of the electric acupuncture treatment group is better than the acupoint injection group.