| Purpose:To verify The clinical efficacy and safety of thumb-tack needle for subcutaneous embedding in the treatment of moderate dry eye(DE)with "liver meridian heat" by observing the effects of thumb-tack needle for subcutaneous embedding on relevant indexes in patients with moderate dry eye with "liver meridian heat".Material and method:From May 2022 to November 2022,72 patients diagnosed with moderate dry eye "liver meridian heat" in the ophthalmology clinic of the Second Hospital of Liaoning University of Traditional Chinese Medicine were randomly divided into 36 patients in the test group(thumb-tack needle for subcutaneous embedding plus basic treatment)and36 patients in the control group(basic treatment).Control group:basic treatment(0.3%vitreous acid sodium drops),1 drop each time,5 times a day for 2 weeks.Test group: thumb-tack needle for subcutaneous embedding(single-use sterile snap-needle,size: 0.18*1.35mm)and basic treatment(0.3%vitreous acid sodium drops).The acupuncture points are taken according to the symptoms,and the grouping is:Two acupuncture points in the eight zones and eight acupuncture points snap-needle subdivisions of the liver and gallbladder zone and the upper jiao zone are treated,both incorporated into the eye ocular unilateral acupuncture points.Patients were kept in the needle for 48 h,rested for 1 day,and pressed the buried needle for 1 minute every 4 hours(at 8:00,12:00,16:00 and 20:00)every day during the period of needle retention.The treatment was continuous for 2 weeks with a total of 5 buried needles.We observed the changes in the scores of the Chinese Dry Eye Questionnaire,the changes in the scores of Chinese medicine syndrome,the examination of the Oculus Keratograph dry eye instrument [First Non-Invasive Tear Break-Up Time(NIBUTf),Average Non-Invasive Tear Break-Up Time(NIBUTav),Schirmer I test,Corneal fluorescein staining,counted the total effective rate after treatment and performed statistical analysis to draw conclusions.In this study,SPSS 26.0 statistical software was used to statistically analyze the data of of the two groups of patients before and after treatment and P < 0.05 was considered a statistically significant difference.Results:1.General information:Age of the test group(55.31±14.35)years and The age of the control group was(54.19±15.43)years.A total of 36 patients in the test group,of whom 15 were male and 21 were female.In the control group,there were 36 patients,including 12 males and24 females.The duration of disease was(5.28±3.12)months in the test group and(6.08±3.56)months in the control group.There was no statistically significant difference in age,sex,or duration of disease between the test and control group cases(P=>0.05)and were comparable.2.For NIBUTf : The NIBUTf before treatment was(5.38±1.96)s in the test group and(5.93±2.86)s in the control group,and the NIBUTf before treatment was not statistically different between the two groups(P=0.341>0.05),which was comparable.After treatment,the NIBUTf was(11.09±4.06)s in the test group and(6.59±2.94)s in the control group,and the NIBUTf of the test group was higher than that of the control group(P<0.001),with statistically significant differences;When compared before and after treatment within the group,the NIBUTf in the test group was higher than that before treatment(P< 0.01),and the difference was statistically significant,while the NIBUTf in the control group was not statistically significant when compared before and after treatment,P> 0.05.3.For NIBUTav : Before treatment,NIBUTav in the test group was(8.73±3.98)s,and NIBUTav in the control group was(9.84±4.28)s.There was no statistical difference in NIBUTav between the two groups before treatment(P=0.295>0.05),which was comparable;after treatment,NIBUTav in the test group was(14.79±3.60)s,and the test group’s NIBUTav was higher than that of the control group(P<0.001),and the difference was statistically significant;compared before and after treatment within the group,NIBUTav after treatment was higher than that before treatment in the test group(P<0.01),and the difference was statistically significant,while NIBUTav before and after treatment in the control group,P>0.05,was not statistically significant.4.Chinese dry eye questionnaire score: Before treatment,the Chinese dry eye questionnaire score was(11.69±2.27)in the test group and(11.67±2.47)in the control group,and there was no statistical difference between the Chinese dry eye questionnaire scores of the two groups before treatment(P=0.961>0.05),which was comparable;after treatment,the Chinese dry eye questionnaire score was(8.44±1.84)in the test group and(9.50±1.83)in the control group.After treatment,the Chinese Dry Eye Questionnaire score was(8.44±1.84)in the test group and(9.50±1.83)in the control group,and the Chinese Dry Eye Questionnaire score in both groups decreased significantly compared with that before treatment,and the difference was statistically significant(P<0.001),and the efficacy of patients in the test group improved significantly compared with that in the control group(P=0.017<0.05),and the difference was statistically significant.5.Schirmer I(5min): before treatment,Schirmer I(5min)of the test group was(5.00±2.03)mm,and Schirmer I(5min)of the control group was(5.19±2.40)mm,there was no statistical difference between the two groups before treatment(P=0.712> 0.05),which was comparable;After treatment,the Schirmer I(5min)of the test group was(7.50±2.06)mm and that of the control group was(6.42±2.22)mm,and the Schirmer I(5min)of both groups was significantly improved compared with that before treatment,and the difference was statistically significant(P<0.001),and the efficacy of patients in the test group was better than that in the control group(P=0.036<0.05),and the difference was statistically significant.6.FL(score): Before treatment,the FL(score)of the test group was(2.33±0.828)and the FL(score)of the control group was(2.56±0.773),there was no statistical difference between the FL(score)of the two groups before treatment(P=0.243>0.05),which was comparable;after treatment,the FL(score)of the test group was(1.25±0.554)and the FL(score)of the control group was(1.83±0.775).After treatment,the FL(score)of the test group was(1.25±0.554)and the FL(score)of the control group was(1.83±0.775),and the FL(score)of both groups was lower than that before treatment,and the difference was statistically significant(P<0.001),and the efficacy of the test group was significantly better than that of the control group,and the difference was statistically significant(P<0.001).7.Chinese medicine syndrome score: before treatment,the Chinese medicine syndrome score of the test group was(16.61±3.29)and that of the control group was(16.17±2.91),there was no statistical difference between the two groups before treatment(P=0.546>0.05),which was comparable;after treatment,the Chinese medicine syndrome score of the test group was(9.89±2.20)and that of the control group was(12.11±2.58).After treatment,the Chinese medicine symptom score of the test group was(9.89±2.20)and that of the control group was(12.11±2.58),and the Chinese medicine symptom score of the two groups was significantly lower compared with that before treatment(P<0.001),and the difference was statistically significant.And the efficacy of patients in the test group was better than that in the control group,and the difference was statistically significant(P<0.001).8.Efficacy Assessment:In the test group,2 cases(5.6%)were clinically cured,14 cases(38.9%)were significantly effective,17 cases(47.2%)were effective,and 3 cases(8.3%)were ineffective,with an overall effective rate of 91.7%.In the control group,0 cases(0%)were clinically cured,6 cases(16.7%)were significantly effective,18 cases(50%)were effective and 12 cases(33.3%)were ineffective,with an overall effective rate of 66.7%.And the efficacy of the test group was significantly better than that of the control group(P=0.001<0.01).Conclusion:1.The combination of thumb-tack needle for subcutaneous embedding with vitreous acid sodium drops and vitreous acid sodium drops alone was effective in improving tear secretion,corneal epithelial damage,Chinese Dry Eye Questionnaire score,and Chinese medicine syndrome score in patients with moderate dry eye with liver meridian heat.However,in terms of improving the stability of the tear film,the efficacy of thumb-tack needle for subcutaneous embedding combined with vitreous acid sodium drops was clear,while vitreous acid sodium drops alone had no significant improvement.2.The combination of thumb-tack needle for subcutaneous embedding and vitreous acid sodium drops improved the tear film stability,tear secretion,corneal epithelial damage,Chinese Dry Eye Questionnaire score,and Chinese medicine syndrome score of patients with moderate dry eye liver meridian heat better than vitreous acid sodium drops alone.3.No adverse events were found during the treatment of patients with moderate dry eyes with liver meridian heat in the combination of thumb-tack needle for subcutaneous embedding with vitreous acid sodium drops and vitreous acid sodium drops alone,both of which had a good safety profile. |
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