Analysis Of The Correlation Between Sudden Deafness And Some Blood Parameters In Different Age Groups

ObjectiveTo investigate the relationship between the prognosis of sudden deafness in different age groups and different subtypes and related hematological parameters through a retrospective clinical study,in order to provide clues and basis for clinical treatment and prognostic assessment of sudden deafness.MethodsThis study retrospectively analyzed the clinical data of 342 patients with sudden deafness admitted to the Department of Otolaryngology-Head and Neck Surgery of the First Affiliated Hospital of Dali University from November 2018 to August 2022,screened according to the inclusion and exclusion criteria,and divided the patients into the minor group(<18 years old),the young and middle-aged group(18-59 years old),and the elderly group(≥60 years old)according to age,and collected the relevant blood routine in the study subjects Inflammatory indexes: white blood cells(WBC),lymphocytes(LYM),neutrophils(NEUT),and neutrophils/lymphocytes(NLR),platelets/lymphocytes(PLR),monocytes/lymphocytes(MLR);lipid-related indexes:cholesterol(TC),triglycerides(TG),low-density lipoprotein(LDL-C),high-density lipoprotein(HDL(C);coagulation-related indexes: prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),platelets(PLT),mean platelet volume(MPV).The data of the corresponding three groups of healthy individuals from our physical examination center were also collected as a control group according to the number of patients in each year group.Statistical analysis was performed using SPSS25.0 to compare the relationship between different ages and types of sudden deafness and efficacy,the comparison of blood relationship between the sudden deafness group and the control group,and the relationship between efficacy and blood parameters in the sudden deafness group.Result1.There was no statistical difference in the results of comparing blood parameters between the immature sudden deafness group and the control group;there was no statistical difference in the relationship between the efficacy and blood parameters in the immature group.2.In the comparison of blood parameters between the young and middle-aged deafness group and the control group,WBC,NEUT,LYM,NLR and TC were higher in the deafness group than in the control group,while LYM was lower than in the control group,and the differences were statistically significant(P<0.05);the differences in WBC,NEUT,NLR,TC and LDL between different efficacy groups were statistically significant(P<0.05).3.In the comparison of blood parameters between the deafness group and the control group,WBC,NEUT,NLR,PLR,TC,TG,LDL and FIB in the deafness group were higher than those in the control group,while LYM and APTT were lower than those in the control group,and the differences were statistically significant(P<0.05);the differences in WBC,NEUT,LYM,NLR,PLR and TC between different efficacy groups were statistically significant(P<0.05).The differences in WBC,NEUT,LYM,NLR,TC and HDL were statistically significant(P<0.05).4.In the relationship between the efficacy of patients with different age groups and different types of sudden deafness,the total effective rate of treatment in the young and middle-aged group was higher than that in the elderly group,and the difference was statistically significant(P < α’,α’= 0.017).There was a statistically significant difference in the efficacy between the low-frequency decline group and the total deafness group(P< α’,α’ = 0.0083).Conclusion1.there was no correlation between the onset and efficacy of sudden deafness in immature patients and the blood parameters studied.2.In young and middle-aged patients with sudden deafness,the inflammatory parameters were mainly higher than in the same age group,suggesting a possible correlation with their morbidity and prognosis,with higher values of WBC,NEUT and NLR being associated with worse outcome.3.In elderly patients with sudden deafness,inflammatory markers and lipid markers were mainly higher than in the same age group,suggesting that they may be related to their onset;among them,WBC,NEUT,LYM,NLR and TC affect their prognosis.4.Age and subtypes are factors influencing the prognosis of sudden deafness,with the highest treatment efficiency in young and middle-aged patients,followed by pre-adolescents,and worse in elderly patients;among the subtypes,low-frequency descending type is the most effective,followed by high-frequency descending type,and flat and total deafness are less effective.