Clinical Observation Of Qinglihuazhi Decoction On Non-alcoholic Fatty Liver Disease (Dampness-heat Syndrome)

Objective: To observe the clinical effectiveness and safety of Qinglihuazhi decoction in the treatment of non-alcoholic fatty liver disease with dampness-heat Syndrome.Methods: A total of 66 patients with non-alcoholic fatty liver disease with dampness-heat Syndrome who met the inclusion criteria were selected.They were randomized into experimental and control groups.The experimental group(33 cases)and the control group(33 cases)was treated with Qinglihuazhi decoction and Polyene phosphatidylcholine capsules for a total of 12 weeks,and both groups received health education.Changes in TCM syndrome scores,laboratory indices(ALT,AST,GGT,TC,TG),ultrasound of the liver and controlled attenuation parameters(CAP)were observed and recorded before and after treatment in both groups,and recording patients’ adverse reactions in a timely manner.The data obtained was entered into Excel in tabular form and the data obtained was statistically analysed using SPSS26.0 statistical software to draw conclusions.Results:(1)Comparison of general information: the comparison of gender and age between the two groups of patients was comparable,P>0.05,no statistical difference.(2)Comparison of laboratory indexes and their efficacy: the comparison of ALT,AST,GGT,TC and TG between the two groups before treatment was comparable,P>0.05,no statistical significance;after treatment,the laboratory indexes of both groups were lower than before,P<0.01,the difference was statistically significant;after treatment,there was a statistically significant difference in the improvement of AST,TC and TG in the test group compared with the control group There was no statistically significant difference in ALT and GGT(P>0.05);the overall effective rate of the test group was statistically significant compared with the control group(P < 0.05).(3)Comparison of the efficacy of CAP: the inter-group comparison of CAP before treatment was comparable between the two groups of patients,P > 0.05,with no statistical significance;the intra-group comparison between the two groups after treatment was statistically significant(P < 0.001),the inter-group comparison of CAP values after treatment was statistically significant(P<0.05),and the comparison of the total effective rate between the two groups was statistically significant(P< 0.05).(4)Comparison of the efficacy of liver ultrasound: the total effective rate of ultrasound efficacy was 74.2% in the experimental group,better than 48.4% in the control group(P<0.05),and the difference was statistically significant.(5)Comparison of TCM symptoms and their efficacy:the comparison of TCM symptoms scores between the two groups before treatment was not statistically significant(P > 0.05)and was comparable;the intra-group comparison between the two groups after treatment was statistically significant(P<0.001);the comparison of TCM symptoms scores between the groups after treatment was statistically significant(P<0.05).Conclusion: Both Qinglihuazhi decoction and Polyenyl Phosphatidyl Choline Capsules can relieve the clinical symptoms of TCM in patients with non-alcoholic fatty liver disease caused by dampness and heat,and help to reduce liver enzymatic levels and lipid levels,as well as improve liver ultrasound and CAP levels,thus acting as an anti-inflammatory,lipid regulator,hepatocyte protector and improving liver damage.The efficacy of choosing Qinglihuazhi decoction in treating patients with non-alcoholic fatty liver disease with damp-heat entrapment is overall better than taking oral polyene-phosphatidylcholine capsules for the treatment of non-alcoholic fatty liver disease.Qinglihuazhi decoction has a good therapeutic effect on non-alcoholic fatty liver disease.