Clinical Evaluation Of Soft Liver Particles In The Treatment Of Non-Alcoholic Simple Fatty Liver(Obstruction In Humid Heat)

Object:Taking the patients with non-alcoholic simple fatty liver(damp-heat obstruction syndrome)as the research object,the clinical efficacy of Huazhurogan granules in the treatment of non-alcoholic simple fatty liver(damp-heat obstruction syndrome)was observed through the before and after the control experiment,providing objective basis for the clinical application of this drug and reliable choice for the clinical treatment of this disease.Methods:In this study,50 patients with non-alcoholic simple fatty liver(damp-heat obstruction syndrome)were selected,all from the outpatient department of liver,spleen and stomach of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from August 2020 to June 2022.The patient was given Huazhurogan granules,told the patient to take with boiling water,1 bag at a time,3 times a day.Follow-up and review at 12 weeks,12 / 24 weeks(i.e.,V1,12,24 and V3 visits).In the follow-up review(V2 visit)after 12 weeks of medication,if the patient’s imaging examination is insufficient to diagnose fatty liver,the clinical treatment end point has been achieved and can be discharged.Resluts:1.A total of 50 patients were included in this study without shedding.2.The gender composition of the enrolled patients was more male than female,mostly between 45 and 60 years old.3.There were no significant differences in waist circumference before and after treatment(P > 0.05),but significant differences in body weight and BMI(P < 0.05).4.The TCM syndrome score of patients after treatment was significantly lower than that before treatment,and the change was significantly different(P < 0.05).5.There was no significant change in ALT before and after treatment(P > 0.05),while there was significant difference in γ-GT(P < 0.05).6.TC and TG levels of patients after treatment were significantly decreased compared with those before treatment,and the results were statistically significant(P < 0.05).7.The ratio of liver/spleen CT after treatment was significantly improved compared with that before treatment,and the results were statistically significant(P < 0.05).8.No adverse events occurred in this study.Conclusion:1.Huazhurogan granules can improve BMI index,blood lipid level and serum γ-GT level in patients.2.Huazhurogan granules can reduce the clinical symptoms of TCM.3.Huazhurogan granules can improve the CT ratio of liver / spleen.