| Objective:In this study,Yiqi yangyin prescription was applied to treat patients with chronic heart failure(Qi-Yin deficiency).It was expected to improve physical fitness,relieve body fatigue and improve life by intervening in the treatment of patients with chronic heart failure.Through standard clinical study to observe the improvement of fatigue condition of chronic heart failure patients with Qi-Yin deficiency and the situation and adverse reaction events,explore the advantages of traditional Chinese medicine(TCM)prescription in improving fatigue,and evaluate the prescription of nourishing Qi and Nourishing Yin.It is intended to provide a new way for the clinical treatment of fatigue in patients with chronic heart failure.Methods:A randomized controlled clinical trial was conducted in this study.A total of 80 patients with chronic heart failure of Qi-Yin deficiency who met the diagnostic criteria and had sustained fatigue were enrolled and randomly divided into treatment group(n=40)and control group(n=40).The study period was 4 weeks.The control group was given standard treatment of Western medicine,and the treatment group was given standard treatment of Western medicine+Qi-nourishing formula.In this study,the clinical manifestations of the two groups were observed before treatment,and in the first,second,third and fourth weeks after treatment,respectively,and the scores of BFI-C,MFI-20-C,MLHFQ,TCM syndrome score,adverse reactions and improvement of cardiac function were recorded.The clinical efficacy and safety of Yiqi yangyin prescription were evaluated by numerical quantification.SPSS 26.0 software was used for statistical analysis.The number of cases and constituent ratio were used for enumeration data description,and?~2test was used for inter-group comparison.The measurement data conform to the normality test,using?x±s description.The data analysis employed repeated measurements of ANOVA,parallel Mauchly tests,and Greenhouse-Geisser corrections.Results:Before treatment,there was no significant statistical difference in each index between the two groups,which was comparable(P>0.05).After treatment,the b ICI-C scores of the treatment group were 22.93±2.46,13.20±2.26,10.90±2.52,9.05±2.77 at the first,second,third and fourth weeks,respectively.MFI-20-C integral was51.40±2.00,38.20±5.26,34.08±3.72,29.60±3.96,MLHFQ scores were 53.00±4.11,35.75±5.25,30.78±4.17,25.68±3.40,TCM syndrome scores were 9.78±1.78,5.93±1.60,3.28±1.34,2.33±1.16,all above indexes were better than those of control group(P<0.05).Repeat measure ANOVA was performed for each score of patients in both groups,b FI-c score(treatment factor*time:F=676.470,P<0.05),MFI-20-C score(treatment factor*time:F=21.423,P<0.05),MLHFQ score(treatment factor*time:F=118.626,P<0.05),TCM syndrome score(treatment factor*time:F=3.750,P<0.05),treatment factors and time all had an interaction in the four scores.No adverse events were observed from the beginning to the end of the study,and NT-pro BNP decreased significantly compared with before treatment(P<0.05).Conclusion:Nourishing Qi and nourishing Yin can effectively improve the fatigue status of chronic heart failure patients with Qi-Yin deficiency,improve traditional Chinese medicine syndromes and the life of patients,and no adverse events have been observed.It has reliable clinical application value to reduce NT-pro BNP level and improve cardiac function. |
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