Clinical Study On Yiqi Huoxue Lishui Recipe In Treating Chronic Heart Failure With Qi Deficiency And Blood Stasis

Objective:To evaluate the clinical efficacy and safety of YiQi HuoXue LiShui Decoction combined with conventional western medicine in the treatment of chronic heart failure syndrome and Qi deficiency blood stasis water retention syndrome,analyze the possible mechanism of its efficacy,and explore new ideas for the treatment of heart failure with integrated traditional Chinese medicine and western medicine.Methods:60 cases with chronic heart failure syndrome and Qi deficiency blood stasis water retention syndrome were collected from July 2017 to December 2017 in the cardiology department of Guanganmen Hospital of Chinese Academy of Chinese Medicine.All the patients met the dual diagnostic and inclusion criteria of traditional Chinese medicine and Western medicine.All patients were randomly divided into the treatment group and the control group according to the random number table.In the control group,30 patients were treated with routine western medicine,and 30 cases in the treatment group were given YiQi HuoXue LiShui Decoction combined with conventional western medicine.Both groups were treated for 4 weeks.The observation indicators including TCM syndrome scores,NT-proBNP,left ventricular ejection fraction,6-minute walking distance,and Minnesota heart rate scale scores before and after the initial diagnosis of treatment.And all of the adverse reactions during the trial were recorded.We also observed whether there were cases that need to be removed and whether there were any shedding cases.Finally,we filled the experimental case report truthfully,and compared the clinical efficacy and safety of the two groups through statistics.Results:During the experimental period,1 case in the treatment group and 1 case in the control group fell off,and there were 29 effective cases in each group.The change of TCM syndrome scores before and after treatment in both groups was statistically significant by paired sample t test(P<0.001).And the decrease of the scores of TCM symptom in the treatment group was significantly higher than the control group(P<0.05),indicating the reduction of the score in the treatment group was more significant.The increase of the 6-minute walking distance in the treatment group was significantly higher than in the control group(P<0.05).However,for the decrease of NT-proBNP and Minnesota heart rate scale scores and the increase of LVEF,there were no significantly difference between the two groups(P>0.05).In the course of the experiment,there were no drug-related adverse events in both groups of patients.Conclusion:YiQi HuoXue LiShui Decoction combined with conventional western medicine is effective in treating chronic heart failure syndrome and Qi deficiency blood stasis water retention syndrome.Compared with patients only treated by conventional western medicine,the combined treatment can significantly relieve the TCM syndrome scores and improves the 6-minute walking distance.This research promoted the theory of traditional Chinese medicine,and organically combined the theory of traditional Chinese medicine with the theory of Western medicine.It has a good prospect of promotion in the clinical treatment of heart failure patients,and there is a great space to explore in the future.