Clinical Observation On Treatment Of Chronic Heart Failure(Qi Deficiency And Blood Stasis Syndrome) With Buzhong Yiqi Decoction And Danshen Decoction

Objective:By observing the effects of Bu Zhong Yiqi Decoction combined with Danshen Decoction plus and minus on the clinical efficacy of patients with chronic heart failure(Qi deficiency and blood stasis),we evaluated the efficacy of Bu Zhong Yiqi Decoction combined with Danshen Decoction plus and minus in the treatment of chronic heart failure and accumulated experience for the evidence-based treatment of chronic heart failure in Chinese medicine.Methods:72 patients from the outpatient department of cardiovascular disease at the First Hospital of Heilongjiang University of Traditional Chinese Medicine were included in this study,all of whom met the diagnostic criteria,inclusion and exclusion criteria and were randomly divided into control and treatment groups,with 36 cases in each group.Patients in the control group were treated with the conventional Western medical treatment regimen for CHF according to the guidelines,while the latter group was treated with the combined application of Bu Zhong Yiqi Decoction combined with Danshen Decoction plus and minus on the basis of the control group for a total treatment period of 3 weeks.The changes of NYHA cardiac function classification,TCM evidence score,TCM evidence efficacy,N-terminal brain natriuretic peptide precursor(NT-pro BNP),6-minute walk test(6MWT),Minnesota Heart Failure Quality of Life Scale score(MLHFQ)and related safety indexes were recorded and compared between the two groups before and after treatment.Results:During the study period,a total of 7 study cases were shed: 5 cases in the control group and 2 cases in the treatment group.Finally,65 cases were completed: 31 cases in the control group and 34 cases in the treatment group.1.The differences in gender,age,disease duration,primary disease,NYHA classification,TCM evidence score,plasma NT-pro BNP,6MWT,and MLHFQ between the two groups before treatment were not statistically significant(P> 0.05),respectively,and could be compared.2.Comparison of NYHA grading efficacy: The NYHA grading situation improved in both groups at the end of treatment,and the total effective rate of the treatment group(85.29%)was better than that of the control group(61.29%),and the comparison of the results of the two groups was statistically significant(P < 0.05).3.Comparison of TCM syndrome points: the total TCM syndrome points of patients in both groups decreased at the end of treatment compared with those before treatment(P < 0.05),and the difference was statistically significant.In improving the symptoms of shortness of breath,weakness,chest pain and spontaneous sweating,the treatment group was significantly better than the control group(P < 0.05),and the difference was statistically significant.4.Comparison of the efficacy of TCM symptoms: both groups showed improvement in TCM symptoms at the end of treatment,and the total effective rate of the treatment group(88.24%)was better than that of the control group(74.19%),and there was a statistical difference between the results of the two groups(P < 0.05).5.Comparison of plasma NT-pro BNP levels: plasma NT-pro BNP levels decreased in both groups at the end of treatment,P < 0.05,with a statistically significant difference.The comparison between groups was P < 0.05,which was statistically different,indicating that the plasma NT-pro BNP levels in the treatment group decreased more than those in the control group.6.Comparison of 6MWT : the 6-minute walking distance after the end of treatment was improved in both groups compared with the previous one,P <0.05,with statistically significant differences.P < 0.05 for the comparison between groups,with statistical difference,indicating that the 6-minute walking distance in the treatment group was improved more than that in the control group.7.Comparison of MLHFQ: The MLHFQ scores of patients in both groups decreased at the end of treatment compared with before,P < 0.05,and the difference was statistically significant.The difference was statistically significant.P < 0.05 was statistically different between the groups,indicating that the MLHFQ scores were lower in the treatment group than in the control group.Conclusion:The combination of Bu Zhong Yiqi Decoction combined with Danshen Decoction plus and minus with conventional western medicine can significantly reduce the TCM syndrome score of patients with chronic heart failure(Qi deficiency and blood stasis),improve clinical symptoms such as shortness of breath,weakness,chest pain and spontaneous sweating,reduce NTpro-BNP level and improve prognosis,improve exercise tolerance and reduce MLHFQ score,thus improving patients’ cardiac function and quality of life to a certain extent,and its efficacy is better than that of western medicine treatment alone.