Clinical Observation Of Tonifying Kidney And Nourishing Liver Prescription In The Treatment Of Parkinson’s Disease Dyskinesia With Liver And Kidney Deficiency

Objective: In this study,we observed the clinical efficacy of tonifying kidney and nourishing liver prescription in the treatment of Parkinson’s disease dyskinesia with liver and kidney insufficiency,and provided the basis of clinical efficacy for the treatment of Parkinson’s disease dyskin esia by combining traditional Chinese and Western medicine.Methods: Methods A total of 80 patients with dyskinesia of liver and kidney insufficiency Parkinson’s disease were selected from January 2021 to January2022 in the ward and outpatient department of encephalopathy and geriatrics of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,and they were divided into treatment group and control group by random number table method,with 40 patients in each group.The control group was treated with western medicine,and the treatment group was additionally treated with tonifying kidney and nourishing liver prescription.The course of treatment was 8 weeks.Before and after treatment,the TCM Syndrome Rating Scale,Unified Dyskinesia Rating Scale(UDys RS),Parkinson’s Disease Dyskinesia Scale-26(PDYS-26),Involuntary Movement Rating Scale(AIMS),Changes in UPDRS II,III,IV-A,Parkinson’s disease quality of life scale(PDQ-39)score,and Hoehn-Yahr classification in the Unified Parkinson’s Disease Rating Scale(UPDRS).All clinical data were statistically analyzed using SPSS25.0 statistical software,and the results of the study were comprehensively evaluated.Results:(1)TCM syndrome effect: After 8 weeks of treatment,the total effective rate of the treatment group was 86.84%,which was significantly higher than that of the control group(61.11%),the difference was statistically significant(P<0.05).(2)TCM syndrome score: TCM syndrome score of 2 groups after treatment was lower than before treatment,the difference was statistically significant(P<0.05);The score of the treatment group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).(3)UDys RS scale,PDYS-26 scale,AIMS scale: After 8 weeks of treatment,the scores of UDys RS scale,PDYS-26 scale,and AIMS scale in the two groups all decreased to varying degrees,and the difference was statistically significant(P<0.05);while the score of the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05).(4)UPDRS II,III,IV-A scales: the scale scores of the two groups of patients were decreased compared with those before treatment,and the difference was statistically significant(P<0.05);the scores of the treatment group were significantly lower than those of the control group,and the difference was statistically significant Academic significance(P<0.05).(5)Quality of life scale(PDQ-39),Hoehn-Yahr grading scale: after treatment,the scores of the two groups of patients were decreased compared with those before treatment,and the difference was statistically significant(P<0.05);the score of the treatment group was better than that of the control group,the difference was Statistically significant(P<0.05).Conclusion(s):(1)The prescription of tonifying kidney and nourishing can improve TCM syndromes in patients with Parkinson’s disease dyskinesia with liver and kidney deficiency;(2)The prescription of tonifying kidney and nourishing can improve patient’s motor function,dyskinesia symptoms and involuntary movement symptoms,and reduce the impact on patient’s daily life;(3)The prescription of tonifying kidney and nourishing can significantly improve the patient’s disease severity and quality of life.