Clinical Observation Of Traditional Chinese Medicine Compound Cholecystrin Decoction In The Treatment Of Gallbladder Polyps(Sputum Turbid Connotations)

The first part is ep idemiological investigation of gallbladder polypObjective:Objective:To investigate the gender,age,body mass index(BMI),blood lipids,fasting blood glucose(GLU),dietary preferences and living habits of patients with gallbladder polyp(PLG),and analyze and summarize the characteristics of the disease and clinical characteristics,so as to provide practical and theoretical basis for the prevention and early diagnosis and treatment of this disease.Methods:The research objects included 85 patients with gallbladder polyps newly diagnosed from the Physical Examination Center of The Affiliated Hospital of Shandong University of Traditional Chinese Medicine from June 2020 to October 2021(study group),and 85 healthy people without gallbladder disease who underwent physical examination during the same period(control group).General information such as name,sex,age,BMI,eating habits,smoking,exercise,etc.Fasting blood glucose and blood lipids were measured.General information,age distribution of gallbladder polyp group and laboratory indicators(BMI,GLU,TC,TG,LDL-C and HDL-C)of the two groups were compared and statistically analyzed.Results:1.Gallbladder polyps are mostly found in middle-aged patients aged 45-59 years,with a detection rate of 49.4%,followed by 60-75 years old,with a detection rate of 32.9%,and the lowest prevalence of young people aged 20-44 years,with a detection rate of 17.7%.The detection rate of gallbladder polyps is higher in men(66%)than in women(33%),and in all age groups men are higher than women.2.Distribution of risk factors for gallbladder polyps,frequent consumption of fried(80.0%)in terms of dietary habits accounted for the first place,followed by no/light physical activity(78.8%),the third place was regular consumption of seafood(64.2%),followed by regular consumption of milk(52.9%),high carbohydrate(50.6%),nuts(47.1%),smoking cessation or smoking(47.1%),in terms of blood lipids,fasting blood glucose,obesity index indicators,TC increase(74.1%),1st place,It was followed by overweight or obesity(62.4%),followed by an increase in TG(54.1%),an increase in GLU(37.6%),an increase in LDL-C(34.1%),and a decrease in HDL-C(30.6%).3.According to gender analysis,the top 3 of the main risk factors for men are regular fried,no/mild sports,elevated TC,overweight or obesity;the top 3 women are those with elevated TC,frequent fried,and seafood.Men often consume fried,quit smoking or smoking,no/mild sports,elevated TC,overweight or obesity exposure is higher than in women(P<0.05).The exposure rate of regular consumption of nuts in women is higher than that in men(P<0.05).4.In the 20-44 age group,the top two risk factors were regular fried(73.3%),with elevated TC(66.7%);in the 45-59 age group,the top two were no/light physical activity(88.1%),frequent fried(78.6%),elevated TC(78.6%),overweight or obesity(78.6%);in the 60-75 age group,the top two were regular fried(85.7%),no/light sports(82.1%),In different age groups,the exposure rate of gallbladder polyps in the 45-59 age group was more prominent than in other age groups(P<0.05).Conclusion:1.The detection rate of gallbladder polyps in the male group is higher than that of women,and through the stratification of age and sex,it is found that the disease detection rate in middle-aged people is the highest,and there are more men than women.2.The distribution of risk factors for gallbladder polyps accounts for the top 3,followed by frequent fried,no/mild physical activity,and elevated TC.3.In terms of dietary lifestyle habits,men often consume fried,quit smoking or smoking,no/mild physical activity,elevated TC,overweight or obesity exposure rates are higher than women(P<0.05).The exposure rate of regular consumption of nuts in women is higher than that in men(P<0.05).4.In different age groups,the exposure rate of gallbladder polyps in the 45-59 age group was more prominent than that of other age groups(P<0.05).The second part is the clinical effect of TCM compound danxieling Decoction on gallbladder polyp(phlegm and turbidness)Objective:To explore the clinical efficacy and safety of TCM compound danxiding Decoction in the treatment of gallbladder polyp(phlegm-turbidium-containing type),and to provide clinical experience and theoretical basis for the treatment of gallbladder polyp.Methods:1.Theoretical research(1)Current research:Chinese and foreign literatures in the past 10 years were reviewed to extract and analyze the relevant discussions and research progress of modern medicine on the etiology,pathogenesis,diagnosis,treatment and prognosis of gallbladder polyp.(2)Traditional Chinese medicine:refer to ancient medical books and learn from the experience of syndrome differentiation and treatment of diseases such as phlegm turbidity and phlegm stasis.Consult the professional literature of TCM prevention and treatment of this disease in the past 20 years,summarize and sort out effective treatment and prescriptions.Summarize the clinical characteristics and the law of pathogenesis,clarify the etiology,summarize the pathogenesis,screen the treatment prescriptions,explore the law of syndrome and treatment,combined with our department’s experience in treating gallbladder polyps with Danxiling Decoction,to supplement and improve the rational prescription of Danxiling Decoction.2.Clinical studiesThe control group received lifestyle interventions,including dietary modifications and weight loss.The experimental group was orally decocted with TCM compound Danxiling decoction on the basis of lifestyle intervention,1 dose per day.3 months later,liver,bile,pancreas,spleen and kidney color doppler ultrasonography,blood lipid,fasting blood glucose,carotid artery color doppler ultrasonography and BMI of patients in the two groups were reviewed.Changes in gallbladder contraction function,cystic wall thickness,maximum length and diameter of polyps,carotid artery plaque,blood lipid and blood glucose levels and BMI were compared for statistical analysis.Results:1.The BMI of the control group decreased significantly before and after treatment(P<0.05);However,there were no significant differences in the maximum diameter of gallbladder polyp,gallbladder contraction function,cystic wall thickness,blood lipid,fasting blood glucose and carotid artery plaque(P>0.05).2.Compared with before and after treatment,the maximum length diameter,TC and BMI of gallbladder polyp were reduced or decreased(P<0.05);There were no significant differences in gallbladder contraction function,wall thickness,TG,HDL-C,LDL-C,fasting blood glucose and carotid plaque(P>0.05).3.After treatment,the maximum length diameter and TC of gallbladder polyp in experimental group and control group were decreased,and BMI was decreased or decreased(P<0.05).There were no significant differences in gallbladder contraction function,wall thickness,TG,HDL-C,LDL-C,fasting blood glucose and carotid plaque(P>0.05).Conclusions:1.Lifestyle interventions can help reduce BMI.2.Danxining Decoction has good clinical efficacy in the treatment of gallbladder polyp,which can help to reduce or decrease the maximum length diameter,TC and BMI of gallbladder polyp.It is an effective prescription for the treatment of gallbladder polyp.Danxiling Decoction combined with lifestyle intervention can reduce TC,BMI and the maximum length and diameter of gallbladder polyp to a greater extent.