| Purpose:In order to observe the clinical efficacy and mechanism of Xifengtongluo granule in the treatment of patients with acute ischemic stroke(syndrome of wind-phlegm-stasis)by tutor Professor Zou Yong,and to provide new ideas and methods for clinical research.Method:A total of 82 cases lost thrombolysis opportunity or refusal of thrombolysis were admitted in the study in Yuhuangding Hospital from January2021 to December 2021,and met the diagnostic criteria of the wind phlegm and blood stasis resistance syndrome,then randomly divided into a control group(n = 41)and a treatment group(n = 41).Patients in the control group received conventional western medicine treatment recommended by the guidelines,such as improving brain metabolism,regulating lipid and anti-platelet aggregation,and those in the treatment group were given Xifengtongluo decoction intravenously on the basis of the control group for 14 days.Observed the total effective rate,NIHSS score,cerebral infarction volume,TCM efficacy score and m RS score between two groups of patients after treatment to evaluate the clinical efficacy.Blood fat(total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),lipoprotein A(LP(A)))and blood homocysteine(Hcy)were used to evaluate the lipid-regulating effect of Xifengtongluo Decoction.Blood coagulation functions(Activated partial thrombin time(ATPP),prothrombin time(PT),fibrinogen(FIB))were used to evaluate the blood-activating effect of XIFENG Tongluo Decoction.Inflammatory factors(tumor necrosis factor(TNF),interleukin-6(IL-6))were used to evaluate the anti-inflammatory effect of Xifeng Tongluo Decoction.SPSS statistical software was used to evaluate the clinical efficacy.Result:(1)A total of 80 cases were completed according to the study protocol,including 40 cases in the treatment group and 40 cases in the control group.(2)The total effective rate(The treatment group was 77.5% and 67.5% in control group),NIHSS score,cerebral infarction volume,TCM efficacy score in treatment group after 14 days were statistically significant difference(P<0.05),indicating that the clinical curative effect of treatment group is better than the control group.The total clinical response rate(The treatment group was 95% and 85% in control group),NIHSS score and m RS score of the treatment group after 90 days were significantly improved compared with the control group(P<0.05),indicating that the treatment group was superior to the control group in terms of long-term efficacy and disability improvement.(3)The changes of blood lipid index,blood homocysteine,coagulation functions and inflammatory factors in the treatment group after treatment were better than those in the control group(P<0.05).It shows that the treatment group has obvious effects on resolving phlegm and promoting blood circulation,regulating lipid,anticoagulant and resisting inflammatory injury.(4)No serious adverse reactions were observed during treatment in both groups.Conclusion:Through the way of tonifying liver and kidney,dispelling wind,dissipating phlegm,activating blood and dredging collaterals,and the mechanism of action of multi-way and multi-action target,Xifeng Tongluo granules could significantly improve the neurological function score,reduce the volume of cerebral infarction,improve the quality of life of patients,reduce the level of total cholesterol,low density lipoprotein cholesterol,homocysteine,increase the level of high density lipoprotein,improve the coagulation function,inhibit the release of inflammatory mediators,so as to significantly improve the clinical efficacy of acute ischemic stroke patients.Professor Zou Yong’s understanding of the etiology and pathogenesis of stroke and the formulation principle of Xifeng Tongluo granules provided new clinical ideas for the treatment of acute ischemic stroke. |
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