| Objective:To observe the effect of Ditan Xifeng Tongluo Decoction on the clinical efficacy and blood lipid of patients with acute cerebral infarction(ACI)(in the meridian wind phlegm stasis syndrome),and to evaluate the medication security.Methods : 60 patients with ACI were randomly divided into the treatment group(n=30)and control group(n=30).The control group was given routine treatment of ACI Western medicine.And the treatment group was treated with Ditan Xifeng Tongluo Decoction on the basis of the control group,daily 1 agent,points 2 times in the morning and evening.The total course is 14 days.After the treatment,three routine examination,blood chemistry,coagulation,the scores of Traditional Chinese medicine(TCM)symptoms,the total curative effect of TCM symptoms,the degree of neurological deficit,the scores of Barthel Index(BI),the scores of Modified Rankin Scale(m RS)and the level of blood lipid were observed and compared between the two groups before and after treatment.And then,all the dates were performed statistical analysis.Results:(1)The comparison of total curative effect of TCM the totalcurative effect of TCM symptoms:After 14 days of treatment,the total effective rate was 90.00% in the treatment group and 66.67%in the control group.The difference was statistically significant(P<0.05).(2)The comparison of total score of TCM the total curative effect of TCM symptoms:After treatment for 14 days,the total score of TCM the total curative effect of TCM symptoms in the treatment group was(14.67±6.26)and the control group was(18.87±7.37),there was significant difference between the two groups before and after treatment(P<0.01),and the same to the two groups after treatment(P<0.05).The treatment group was superior to the control group.(3)The comparison of single TCM symptoms:After 14 days of treatment,the scores of single TCM the total curative effect of TCM symptoms in the treatment group were significantly decreased except feeling diminished(P<0.01),the scores of single TCM the total curative effect of TCM symptoms including the upper limbs failed,tongue skew,language barriers and dizziness in the control group were significantly reduced(P<0.05).It showed that the scores of the upper and lower limbs failed,dizziness and feeling diminished in the treatment group were significantly decreased after treatment(P<0.05),but the other single TCM symptoms had no ststistically difference(P>0.05).(4)The comparison of neurological deficifs:After treatment for 14 days,the scores of neurological deficit in the treatment group was(5.20±3.58)and the control group was(7.53±4.69).The scores in both groups were significantly lower than those before treatment(P<0.01),and the treatment group showed drop more after treatment(P<0.05).The treatment group was superior to the control group.(5)The comparison of BI score:Onset of 3 months,the scores of BI in the treatment group was(85.17±16.27)and the control group was(72.83±20.24).The scores in both groups were significantly higher than those before treatment(P < 0.01),and the treatment group showed rise more after treatment(P<0.05).The treatment group was superior to the control group.(6)The comparison of m RS score: Onset of 3 months,the m RS scores in both groups were significantly lower than those before treatment(P < 0.01),and the treatment group showed reduce more after treatment(P<0.05).The treatment group was superior to the control group.(7)The comparison of blood lipid: Onset of 3 months,there was significant difference between the two group in reducing cholestrol(TCh),triglycerides(TG),low density lipoprotein cholesterol(LDLC)and elevated high density lipoprotein cholesterol(HDL-C)before and after treatment(P < 0.01).And the treatment group showed significantly difference in elevating HDL-C and reducing LDL-C after treatment(P<0.01).(8)The safety evaluation:There were no obvious abnormalities in both groups when observing the blood routine,liver and kidney function,blood glucose,coagulation,electrocardiogram and other indicators.Conclusion:(1)Ditan Xifeng Tongluo Decoction combined with routine Western medicine had a better advantage in improving the total efficacy of TCM the total curative effect of TCM symptoms,total or single TCM the total curative effect of TCM symptoms scores than the treatment with Western medicine alone.(2)Ditan Xifeng Tongluo Decoction combined with routine Westernmedicine can effectively reduce the degree of neurological deficits,improve the ability of daily living,reduce disability,and it better than the use of Western medicine alone.(3)Ditan Xifeng Tongluo Decoction can effectively regulate the level of blood lipids in patients who suffering from ACI.(4)The two group showed high safety during the treatment.In summary,Ditan Xifeng Tongluo Decoction is an effective and safe prescription for the treatment of ACI,and can effectively improve the prognosis and blood lipid levels.So Ditan Xifeng Tongluo Decoction deserves further clinical study. |
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