Clinical Observation Of Jianpi Qushi Recipe Combined With Mesalazine In The Treatment Of Ulcerative Colitis With Spleen Deficiency And Dampness Accumulation

Purpose:To study and evaluate the efficacy of tonifying spleen and eliminating dampness prescription combined with Mesalazine in the treatment of ulcerative colitis with spleen deficiency and dampness accumulation type,and to provide an effective scheme for the treatment of ulcerative colitis with spleen deficiency and dampness accumulation type.Material and method: A total of 50 patients with ulcerative colitis with spleen deficiency and dampness accumulation type,who were hospitalized in the Spleen and Gastric Department of Affiliated Hospital of liaoning University of Traditional Chinese Medicine from January 2019 to December 2020 were selected and divided into two groups according to random number table method,including 25 cases in the test group and 25 cases in the control group.The test group was treated with tonifying spleen and eliminating dampness prescription combined with mesalazine,and the control group was treated with mesalazine,two groups for 12 weeks.To evaluate the remission rate,effective rate,TCM syndrome efficacy and symptom score,improved Mayo score,Baron score,Geboes index,quality of life,safety evaluation and so on.Results:1.Curative effect analysis :(1)Clinical remission: The remission rate of the test group was 80 and that of the control group was 52.There was a significant difference between the two groups(P<0.05).(2)Clinical efficacy: The effective rate was 96% in the test group and 72%in the control group.There was significant difference between the two groups(P<0.05).(3)The curative effect of TCM syndromes: the effective rate of the test group was 96%,the effective rate of the control group was 72%,and there was significant difference between the two groups(P>0.05).2.Analysis of observation index :(1)TCM symptom score: the two groups improved obviously after treatment,And the test group was better than the control group,differences were statistically significant(P<0.05).(2)Modified Mayo score: the two groups improved significantly after treatment,And the test group was better than the control group,differences were statistically significant(P<0.05).(3)Baron endoscopic integration: the degree of mucosal injury after treatment in the two groups was better than before treatment,And the test group was better than the control group,differences were statistically significant(P<0.05).(4)Geboes index: the degree of histological injury after treatment was better than before,And the test group was better than the control group,differences were statistically significant(P<0.05).(5)IBDQ:The quality of life of the two groups was significantly improved after treatment,And the test group was better than the control group,differences were statistically significant(P<0.05).3.Safety index: There were no adverse reactions in the two groups during the course of treatment.There was no significant difference between the two groups before and after treatment(P<0.05).Conclusion:1.Compared with mesalazine,tonifying spleen and eliminating dampness prescription combined with mesalazine in the treatment of ulcerative colitis with spleen deficiency and dampness accumulation type,it can improve the clinical efficacy,TCM syndrome efficacy,intestinal mucosal recovery and histopathological healing.2.In relieving the symptoms of traditional Chinese medicine,the effect of tonifying spleen and eliminating dampness prescription is more prominent than that of mesalazine,which can better improve the symptoms of patients with less fatigue,sleepiness and abdominal distension.3.There were no adverse reactions and no adverse events,which were safe and worthy of clinical application.