| Objective:By detecting the levels of vitamin A,D,CRP,PCT,SAA,WBC,and HB in children with acute upper respiratory tract infection and pneumonia,the correlation between vitamin A,D and common inflammation indicators in children with respiratory tract infection is explored,and the severity of clinical disease can be judged and summarized.Adju VA nt treatment provides scientific basis.Methods:Selected 340 children with respiratory infections who attended the Pediatrics Department of Yan’an University Affiliated Hospital from October 2019 to December2020 as the research subjects,including 80 cases of acute upper respiratory tract infection(upper infection group),105 cases of pneumonia(light type),and pneumonia(severe type).)40 cases were the case group,and 115 children who received the physical examination by the physical examination department during the same period were the control group;all of them were collected on an empty stomach in the morning after admission and peripheral blood was collected to test the serum vitamin A,D,PCT,CRP,SAA,WBC,HB.Compare the above levels of the four groups of children;explore the relationship between vitamin A,D and commonly used inflammatory factors in children with respiratory infections.Results:1.There was no statistical difference in gender and age of children in acute upper respiratory infection group,pneumonia(light)group,pneumonia(severe)group,and control group(P>0.05).2.(1)Serum vitamin A levels M(P25,P75)in the acute upper respiratory tract infection group,pneumonia(light)group,pneumonia(severe)group,and control group were 0.27(0.21,0.37)mg/l and 0.26(0.21),respectively,0.33)mg/l,0.18(0.14,0.25)mg/l,0.34(0.30,0.39)mg/l,the vitamin A level of children with infection is lower than the control group,and the pneumonia(severe)group has the lowest serum vitamin A level,The four groups of children were statistically different(X2=76.321,P=0.000);(2)Vitamin D levels M(P25,P75)in each group were 22.70(16.50,33.25)ng/L and 27.80(19.25,respectively).35.70)ng/L,18.10(10.68,27.55)ng/L,26.70(21.70,33.60)ng/L,similarly,there are statistical differences between the four groups(X2=17.938,P<0.001);(3)Each group Serum WBC levels M(P25,P75)were 9.94(7.44,13.91)× 109/L,8.54(6.68,11.92)× 109/L,15.60(12.26,17.30)× 109/L,7.26(6.17,8.67),respectively×109/L,the WBC level of the pneumonia(severe)group is higher than the other three groups;the four groups are statistically different(X2=81.984,P=0.000);(4)the HB level of each group is M(P25,P75)respectively 126.00(116.00,136.50)g/l,123.00(113.00,132.50)g/l,115.50(102.25,130.00)g/l,127.00(120.00,134.00)g/l;HB in the pneumonia(severe)group is the lowest,four There was a statistical difference between the groups(X2=14.625,P=0.002).After comparison between the groups,it was found that for the four groups of children’s vitamin A and WBC levels,there was no significant difference between the upper influenza group and the pneumonia(light)group,and there was a statistical difference between the remaining groups;the serum vitamin D level of children with severe pneumonia was significantly higher The other 3 groups were low.Compared with the control group and the pneumonia(light)group,the pneumonia(severe)group,and the upper flu group and the pneumonia(severe)group,the HB levels were different(P<0.05).3.(1)Serum CRP levels M(P25,P75)in the acute upper respiratory tract infection group,pneumonia(light)group,pneumonia(severe)group and control group were 10.32(8.03,22.83)mg/l and 9.88(5.07,37.01),respectively mg/l,48.67(29.28,70.88)mg/l,7.92(5.34,9.40)mg/l;compared with the other three groups,the level of CRP in the pneumonia(severe)group was significantly increased(X2=88.578,P=0.000)(2)Serum PCT levels M(P25,P75)of each group were 0.05(0.02,0.25)ug/l,0.10(0.04,0.25)ug/l,1.04(0.25,2.88)ug/l,0.03(0.02),0.05)ug/l;Comparison of PCT levels among the four groups of children showed statistical differences(X2=94.284,P=0.000);(3)Serum SAA levels M(P25,P75)of subjects in each group were 21.45(9.06),121.20)mg/l,24.68(9.07,82.20)mg/l,95.68(45.83,163.43)mg/l,6.99(5.24,9.24)mg/l,the pneumonia(severe)group is higher than the other 3 groups,pneumonia(The level of the mild type)group is similar to that of the upper type group;the difference is statistically significant(X2=121.956,P<0.001);after comparing the CRP,PCT and SAA of the four groups of children,there is no difference between the upper type group and the pneumonia(light type)group.Significant difference(P>0.05);after comparison of other groups,there were statistical differences(P<0.05).Children in the acute upper respiratory tract infection group had a negative correlation between vitamin A and SAA,and the difference was statistically significant(P<0.05);there was no correlation with other inflammatory indicators(P>0.05);vitamin D was also negatively correlated with CRP,PCT,and SAA(P<0.05).There was no significant correlation between vitamin A and vitamin D and WBC and HB,and the difference was not statistically significant(P>0.05).4.In children with acute upper respiratory infection group,vitamin A and SAA were negatively correlated with statistical difference(P=0.020);there was no correlation with WBC,CRP,PCT,HB(P>0.05);vitamin D was also correlated with CRP,PCT,SAA There was a negative correlation(P<0.05).There was no significant correlation between vitamin A,D and WBC and HB in children with Shanggan,and there was no statistical difference(P>0.05).5.Vitamin A in the pneumonia(mild)group was negatively correlated with PCT and CRP(P<0.05);there was no correlation with WBC,PCT,HB(P>0.05);and vitamin D was also negatively correlated with CRP,PCT,SAA,and WBC Correlation(P<0.05);not related to HB(P>0.05).6.Vitamin A and vitamin D in the pneumonia(severe)group were significantly negatively correlated with CRP,PCT,SAA,and WBC(P<0.05);they had nothing to do with HB(P>0.05).Conclusions:(1)The serum vitamin A and D levels of children with respiratory tract infection were lower than those in the physical examination group,and the severe pneumonia group had the lowest serum vitamin A and D levels.(2)The WBC,CRP,SAA,and PCT values of the severe pneumonia group were higher than those of the mild pneumonia group,the upper-influenza group and the physical examination group,and the HB value was lower than the other three groups.(3)Vitamins A,D,and inflammation indicators of children with pneumonia changed,and the levels of the two were negatively correlated,and with the severity of the disease,the lower the serum vitamin A and D,the higher the CRP,PCT,SAA,and WBC;suggesting CRP,PCT,SAA,and WBC play a predictive role in the judgment and assessment of the severity of early pneumonia.There is no correlation between vitamin A,D and HB in children with respiratory tract infection,suggesting that serum vitamin A and D have nothing to do with anemia. |
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